Results 171 to 180 of about 2,582,389 (248)

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype. [PDF]

BMC Genomics
Hanrahan BJ, Chang JK, Milton AM, Lister NC, Dissanayake DSB, Hammond JM, Reis ALM, Deveson IW, Ruiz-Herrera A, Patel HR, Graves JAM, Georges A, Waters PD.   +12 more
europepmc   +1 more source

Minimal Transport Units Govern Oxygen‐Defect Stabilization and Transport for Lightweight Solid Electrolytes

Advanced Science, EarlyView.
Lightweight borate chemistry combined with minimal transport units provides a new pathway for designing lightweight oxide‐ion solid electrolytes. ABSTRACT Solid electrolytes are central to electrochemical energy technologies, including fuel cells, sensors, catalysis, membrane separation, and electrolyser.
Xiaohui Li, Yongkang Zheng, Li Yang, Xiaoge Wang, Yuan Gou, Guanqun Cai, Jie Liu, Cheng Li, Kun Lin, Qiang Li, Mingxue Tang, Junliang Sun, Xianran Xing, Xiaojun Kuang   +13 more
wiley   +1 more source

Accurate genomic predictions for chronic wasting disease in North American elk. [PDF]

G3 (Bethesda)
Seabury CM, Bhattarai EK, Brun M, Johnson CD, Haley NJ, Mitchell GB, Nichols TA.   +6 more
europepmc   +1 more source

Monolayer MoS2 With Ultrahigh Piezoelectricity: From ALD Dose Control to Device Performance

Advanced Science, EarlyView.
This study demonstrates that controlling precursor dosages in atomic layer deposition (ALD) serves to regulate ultrathin oxide quality, which in turn determines sulfurization behavior and MoS2 monolayer continuity. The resulting continuous, low‐defect monolayers enable improved piezoelectric performance and support a flexible slippage sensor, linking ...
Yun Li, Ming Rui Joel Tan, Subhasis Das, Yafei Du, Wenjie Lai, Jiamin Amanda Ong, Yongli He, Yiming Zou, Anatoli Kurkin, Peiwen Huang, Jiajun Liu, Xingyu Chen, Alfred Iing Yoong Tok, Soo Jay Phee, Lioz Etgar, Shlomo Magdassi, Pooi See Lee   +16 more
wiley   +1 more source

Haldane's law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids. [PDF]

Nat Commun
Harbin JP, Shen Y, Abubakar AH, Ellis RE.   +3 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Effects of Hybridization and Triploidization on Transcription of Core Metabolic and Stress Response Genes in Rainbow Trout (<i>Oncorhynchus mykiss</i>) × Brook Trout (<i>Salvelinus fontinalis</i>) Hybrids-Preliminary Results. [PDF]

Curr Issues Mol Biol
Kuciński M, Rożyński R, Ocalewicz K.
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Silene, a versatile model system: from sex and genome evolution to ecology and speciation. [PDF]

New Phytol
Karrenberg S, Bačovský V, Berardi AE, De Cauwer I, Giraud T, Hartmann FE, Hobza R, Hudzieczek V, Marais GAB, Miladin JR, Oxelman B, Papadopulos AST, Sloan DB, Steven JC, Štorchová H, Touzet P, Van Rossum F.   +16 more
europepmc   +1 more source