Transcription dosage compensation does not occur in Down syndrome [PDF]
BMC Biology, 2023 Background The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene’s DNA copy number.
Samuel Hunter +4 more
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Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer [PDF]
Cancer Medicine, 2023 The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present.
Diana M. Bravo‐Estupiñan +6 more
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The sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes. [PDF]
Nature, 2023 A newly identified gene, sex chromosome activation ( SOA ), is a master regulator of dosage compensation in Anopheles gambiae . The Anopheles mosquito is one of thousands of species in which sex differences play a central part in their biology, as only ...
Kalita AI +9 more
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Elastic dosage compensation by X-chromosome upregulation [PDF]
Nature Communications, 2022 The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini +8 more
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Sex Chromosome Dosage Compensation in Insects [PDF]
InsectsDosage compensation (DC) is of crucial importance in balancing the sex-linked gene expression between males and females. It serves to guarantee that the proteins or other enzymatic products encoded by the sex chromosome exhibit quantitative parity ...
Xingcheng Xie +3 more
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RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals. [PDF]
Nat Struct Mol Biol, 2023 In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while females (XX) undergo X inactivation.
Rücklé C +16 more
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
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Extensive protein dosage compensation in aneuploid human cancers. [PDF]
Genome Res, 2022 Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein expression remain poorly understood. To uncover how chromosome copy number changes influence the cancer proteome, we have conducted an analysis of hundreds of human ...
Schukken KM, Sheltzer JM.
europepmc +2 more sources
A sequence motif enriched in regions bound by the
BMC Genomics, 2010 Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood.
Aldecoa Rodrigo +3 more
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The X chromosome in C. elegans sex determination and dosage compensation. [PDF]
Curr Opin Genet Dev, 2022 Abnormalities in chromosome dose can reduce organismal fitness and viability by disrupting the balance of gene expression. Unlike imbalances in chromosome dose that cause pathologies, differences in X-chromosome dose that determine sex are well tolerated.
Meyer BJ.
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