Sex Chromosome Dosage Compensation in Insects [PDF]
InsectsDosage compensation (DC) is of crucial importance in balancing the sex-linked gene expression between males and females. It serves to guarantee that the proteins or other enzymatic products encoded by the sex chromosome exhibit quantitative parity ...
Xingcheng Xie +3 more
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Transcription dosage compensation does not occur in Down syndrome [PDF]
BMC Biology, 2023 Background The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene’s DNA copy number.
Samuel Hunter +4 more
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Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer [PDF]
Cancer Medicine, 2023 The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present.
Diana M. Bravo‐Estupiñan +6 more
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Restricting Dosage Compensation Complex Binding to the X Chromosomes by H2A.Z/HTZ-1 [PDF]
PLoS Genetics, 2009 Dosage compensation ensures similar levels of X-linked gene products in males (XY or XO) and females (XX), despite their different numbers of X chromosomes.
Györgyi Csankovszki
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Dosage Compensation of the Sex Chromosomes [PDF]
Annual Review of Genetics, 2012 Differentiated sex chromosomes evolved because of suppressed recombination once sex became genetically controlled. In XX/XY and ZZ/ZW systems, the heterogametic sex became partially aneuploid after degeneration of the Y or W. Often, aneuploidy causes abnormal levels of gene expression throughout the entire genome. Dosage compensation mechanisms evolved
Christine M Distèche
exaly +3 more sources
Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype [PDF]
BMC GenomicsBackground Lizards have sex determination systems that can differ between even closely related species. These include XY and ZW systems, and thermolabile systems where genes and temperature interact to determine sex.
Benjamin J. Hanrahan +12 more
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Elastic dosage compensation by X-chromosome upregulation [PDF]
Nature Communications, 2022 The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini +8 more
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Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates [PDF]
Nature CommunicationsSex-chromosome dosage poses a challenge for heterogametic species in maintaining the proper balance of gene products across chromosomes in each sex.
Natali Papanicolaou +12 more
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Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]
Nature CommunicationsIn mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei +5 more
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Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows. [PDF]
PLoS Genetics, 2023 The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán +3 more
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