Results 21 to 30 of about 30,369 (277)
Dosage compensation: roX marks the spot [PDF]
Current Biology, 1999 The roX genes of Drosophila produce a transcript that is spliced and polyadenylated but not translated. Recent work has shown that these genes provide an element that the dosage compensation complex of Drosophila uses to initiate its association with the X chromosome.
Lucchesi, John C.
openaire +3 more sources
Dosage Compensation in Drosophila: Its Canonical and Non-Canonical Mechanisms. [PDF]
Int J Mol Sci, 2022 Dosage compensation equalizes gene expression in a single male X chromosome with that in the pairs of autosomes and female X chromosomes. In the fruit fly Drosophila, canonical dosage compensation is implemented by the male-specific lethal (MSL) complex ...
Shevelyov YY +4 more
europepmc +2 more sources
Rapid Evolution of Complete Dosage Compensation in Poecilia [PDF]
, 2021 Dosage compensation balances gene expression between the sexes in systems with diverged heterogametic sex chromosomes. Theory predicts that dosage compensation should rapidly evolve in tandem with the divergence of sex chromosomes to prevent the ...
BA Sandkam (21934700) +3 more
core +2 more sources
When Down Is Up: Heterochromatin, Nuclear Organization and X Upregulation
Cells, 2021 Organisms with highly differentiated sex chromosomes face an imbalance in X-linked gene dosage. Male Drosophila solve this problem by increasing expression from virtually every gene on their single X chromosome, a process known as dosage compensation ...
Reem Makki, Victoria H. Meller
doaj +1 more source
Dosage Compensation in Mammals [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation.
Neil, Brockdorff, Bryan M, Turner
openaire +2 more sources
Dosage compensation evolution in plants: theories, controversies and mechanisms. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 International audienceIn a minority of flowering plants, separate sexes are genetically determined by sex chromosomes. The Y chromosome has a non-recombining region that degenerates, causing a reduced expression of Y genes.
Muyle A +4 more
europepmc +2 more sources
Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]
PLoS Genetics, 2014 Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott +4 more
doaj +1 more source
No evidence for a global male-specific lethal complex-mediated dosage compensation contribution to the demasculinization of the Drosophila melanogaster X chromosome. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster males, the expression of X-linked genes is regulated by mechanisms that operate on a chromosomal scale. One such mechanism, male-specific lethal complex-dependent X-linked dosage compensation, is thought to broadly enhance the ...
Steven P Vensko, Eric A Stone
doaj +1 more source
Scientific Reports, 2021 In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral +3 more
doaj +1 more source
Dosage Compensation: How to Be Compensated…Or Not? [PDF]
Current Biology, 2019 Diverse dosage compensation mechanisms have evolved across species to equalize gene expression between sexes and between the sex chromosomes and autosomes. New results show that two opposite modes of dosage compensation can occur within one species, the monarch butterfly.
Jingyue, Duan, Erica N, Larschan
openaire +2 more sources