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Dosage Compensation: How to Be Compensated…Or Not? [PDF]
Current Biology, 2019 Diverse dosage compensation mechanisms have evolved across species to equalize gene expression between sexes and between the sex chromosomes and autosomes. New results show that two opposite modes of dosage compensation can occur within one species, the monarch butterfly.
Jingyue, Duan, Erica N, Larschan
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Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
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Nuclear Organization and Dosage Compensation [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Dosage compensation is a strategy to deal with the imbalance of sex chromosomal gene products relative to autosomes and also between the sexes. The mechanisms that ensure dosage compensation for X-chromosome activity have been extensively studied in mammals, worms, and flies.
Jennifer C, Chow, Edith, Heard
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Frontiers in Genetics, 2021 How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai +4 more
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Dosage Compensation inDrosophila [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X.
John C, Lucchesi, Mitzi I, Kuroda
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Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development
Cell Reports, 2019 Summary: Dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a model for how genes are targeted for coordinated regulation.
Leila Elizabeth Rieder +2 more
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SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2008 In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome.
Anne Spierer +3 more
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The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex [PDF]
, 2008 Dosage compensation in male Drosophila relies on the X chromosome-specific recruitment of a chromatin-modifying machinery, the dosage compensation complex (DCC). The principles that assure selective targeting of the DCC are unknown.
Grimaud, Charlotte +16 more
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Epigenetics & Chromatin, 2018 Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
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