Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
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Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses [PDF]
BMC Biology, 2020 Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to ...
Katherine E. Larrimore +3 more
doaj +5 more sources
The Drosophila over compensating males gene genetically inhibits dosage compensation in males. [PDF]
PLoS ONE, 2013 Male Drosophila are monosomic for the X chromosome, but survive due to dosage compensation. They use the Male Specific Lethal (MSL) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes along the X ∼1.6-1.8 ...
Chiat Koo Lim, Richard L Kelley
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Role of X chromosome and dosage-compensation mechanisms in complex trait genetics. [PDF]
Am J Hum GenetAbstract The X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated.
Fu Y +4 more
europepmc +5 more sources
Genetic dosage compensation in a family with velo‐cardio‐facial/DiGeorge/22q11.2 deletion syndrome [PDF]
American Journal of Medical Genetics, Part A, 2011 AbstractCytogenetic studies of a male child carrying the 22q11.2 deletion common in patients with velo‐cardio‐facial/DiGeorge syndrome showed an unexpected rearrangement of the 22q11.2 region in his normal appearing mother. The mother carried a 3 Mb deletion on one copy and a reciprocal, similar sized duplication on the other copy of chromosome 22q11.2
Tingwei Guo +2 more
exaly +4 more sources
General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq [PDF]
BMC Genomics, 2011 Background Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to ...
Wolf Jochen BW, Bryk Jarosław
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Genetic compensation: A phenomenon in search of mechanisms. [PDF]
PLoS Genetics, 2017 Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals).
Mohamed A El-Brolosy +1 more
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
doaj +3 more sources
X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]
BMC GenomicsBackground X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner +8 more
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Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes [PDF]
BiomoleculesSex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation.
Joshua Eduful +2 more
doaj +2 more sources