Results 1 to 10 of about 2,582,389 (248)

Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]

PLoS Genetics, 2017
Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa, Koji Makanae, Shintaro Iwasaki, Nicholas T Ingolia, Hisao Moriya   +4 more
doaj   +6 more sources

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses [PDF]

BMC Biology, 2020
Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to ...
Katherine E. Larrimore, Natalia S. Barattin-Voynova, David W. Reid, Davis T. W. Ng   +3 more
doaj   +5 more sources

The Drosophila over compensating males gene genetically inhibits dosage compensation in males. [PDF]

PLoS ONE, 2013
Male Drosophila are monosomic for the X chromosome, but survive due to dosage compensation. They use the Male Specific Lethal (MSL) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes along the X ∼1.6-1.8 ...
Chiat Koo Lim, Richard L Kelley
doaj   +4 more sources

X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]

BMC Genomics
Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi   +8 more
doaj   +2 more sources

Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes [PDF]

Biomolecules
Sex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation.
Joshua Eduful, Lily LeSarge, Györgyi Csankovszki   +2 more
doaj   +2 more sources

Genetic dosage compensation in a family with velo‐cardio‐facial/DiGeorge/22q11.2 deletion syndrome [PDF]

American Journal of Medical Genetics, Part A, 2011
AbstractCytogenetic studies of a male child carrying the 22q11.2 deletion common in patients with velo‐cardio‐facial/DiGeorge syndrome showed an unexpected rearrangement of the 22q11.2 region in his normal appearing mother. The mother carried a 3 Mb deletion on one copy and a reciprocal, similar sized duplication on the other copy of chromosome 22q11.2
Bruno Dallapiccola, Bruno Marino Taussig de Bodonia, Bernice Morrow   +2 more
exaly   +3 more sources

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics. [PDF]

Am J Hum Genet
Abstract The X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated.
Fu Y, Kenttämies A, Ruotsalainen S, Pirinen M, Tukiainen T.   +4 more
europepmc   +4 more sources

Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]

Nature Communications
In mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei, Barry Kesner, Uri Weissbein, Peera Wasserzug-Pash, Priyojit Das, Jeannie T. Lee   +5 more
doaj   +2 more sources

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

iScience, 2021
Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L. Arias-Arias, Luis A. Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez   +16 more
doaj   +1 more source

Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]

PLoS Genetics, 2014
Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott, Jacqueline E Villalta, Qi Zhou, Doris Bachtrog, Michael B Eisen   +4 more
doaj   +1 more source