Results 1 to 10 of about 13,842 (221)

Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]

PLoS Genetics, 2017
Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa, Koji Makanae, Shintaro Iwasaki, Nicholas T Ingolia, Hisao Moriya   +4 more
doaj   +6 more sources

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses [PDF]

BMC Biology, 2020
Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to ...
Katherine E. Larrimore, Natalia S. Barattin-Voynova, David W. Reid, Davis T. W. Ng   +3 more
doaj   +5 more sources

X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]

BMC Genomics
Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi   +8 more
doaj   +2 more sources

Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes [PDF]

Biomolecules
Sex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation.
Joshua Eduful, Lily LeSarge, Györgyi Csankovszki   +2 more
doaj   +2 more sources

The Drosophila over compensating males gene genetically inhibits dosage compensation in males. [PDF]

PLoS ONE, 2013
Male Drosophila are monosomic for the X chromosome, but survive due to dosage compensation. They use the Male Specific Lethal (MSL) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes along the X ∼1.6-1.8 ...
Chiat Koo Lim, Richard L Kelley
doaj   +4 more sources

THE GENETIC BASIS OF DOSAGE COMPENSATION OF ALCOHOL DEHYDROGENASE-1 IN MAIZE [PDF]

Genetics, 1981
ABSTRACT The levels of alcohol dehydrogenase (ADH) do not exhibit a structural gene-dosage effect in a one to four dosage series of the long arm of chromosome one (1L) (BIRCHLER19 79). This phenomenon, termed dosage compensation, has been studied in more detail.
James Birchler, Birchler James A
exaly   +3 more sources

Genetic dosage compensation in a family with velo‐cardio‐facial/DiGeorge/22q11.2 deletion syndrome [PDF]

American Journal of Medical Genetics, Part A, 2011
AbstractCytogenetic studies of a male child carrying the 22q11.2 deletion common in patients with velo‐cardio‐facial/DiGeorge syndrome showed an unexpected rearrangement of the 22q11.2 region in his normal appearing mother. The mother carried a 3 Mb deletion on one copy and a reciprocal, similar sized duplication on the other copy of chromosome 22q11.2
Bruno Dallapiccola, Bruno Marino Taussig De Bodonia, Bernice Morrow   +2 more
exaly   +3 more sources

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics. [PDF]

Am J Hum Genet
Abstract The X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated.
Fu Y, Kenttämies A, Ruotsalainen S, Pirinen M, Tukiainen T.   +4 more
europepmc   +4 more sources

Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation [PDF]

Genetics, 2010
Abstract Several recent studies have suggested that F1 hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome.
Daniel A Barbash, Barbash Daniel A
exaly   +3 more sources

Dissection of X chromosome dosage compensation for quantitative traits in sheep using different statistical models [PDF]

Scientific Reports
Since males and females have different number of X chromosome, different mechanisms have evolved to equalize dosage of gene products from the X chromosome between XX females and XY males.
Farhad Ghafouri-Kesbi, Moradpasha Eskandarinasab   +1 more
doaj   +2 more sources