Results 31 to 40 of about 2,582,389 (248)

THE NATURE OF QUANTITATIVE GENETIC VARIATION IN DROSOPHILA. III. MECHANISM OF DOSAGE COMPENSATION FOR SEX-LINKED ABDOMINAL BRISTLE POLYGENES [PDF]

Genetics, 1977
ABSTRACT Seventeen lines, each homozygous for a different × chromosome but all with a common autosomal genetic background, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character.—The regression coefficient of male mean on female mean using ...
openaire   +2 more sources

Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster.

PLoS Genetics, 2016
Deletions, commonly referred to as deficiencies by Drosophila geneticists, are valuable tools for mapping genes and for genetic pathway discovery via dose-dependent suppressor and enhancer screens.
Hangnoh Lee, Dong-Yeon Cho, Cale Whitworth, Robert Eisman, Melissa Phelps, John Roote, Thomas Kaufman, Kevin Cook, Steven Russell, Teresa Przytycka, Brian Oliver   +10 more
doaj   +1 more source

Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly. [PDF]

PLoS ONE, 2015
In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked ...
Rebecca J Linger, Esther J Belikoff, Maxwell J Scott   +2 more
doaj   +1 more source

Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos. [PDF]

PLoS Genetics, 2015
Early embryogenesis is a unique developmental stage where genetic control of development is handed off from mother to zygote. Yet the contribution of this transition to the evolution of gene expression is poorly understood.
Mathilde Paris, Jacqueline E Villalta, Michael B Eisen, Susan E Lott   +3 more
doaj   +1 more source

Absence of a Faster-X Effect in Beetles (Tribolium, Coleoptera)

G3: Genes, Genomes, Genetics, 2020
The faster-X effect, namely the rapid evolution of protein-coding genes on the X chromosome, has been widely reported in metazoans. However, the prevalence of this phenomenon across diverse systems and its potential causes remain largely unresolved ...
Carrie A. Whittle, Arpita Kulkarni, Cassandra G. Extavour   +2 more
doaj   +1 more source

Autosomal and X-Linked Additive Genetic Variation for Lifespan and Aging: Comparisons Within and Between the Sexes in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2016
Theory makes several predictions concerning differences in genetic variation between the X chromosome and the autosomes due to male X hemizygosity. The X chromosome should: (i) typically show relatively less standing genetic variation than the autosomes,
Robert M. Griffin, Holger Schielzeth, Urban Friberg   +2 more
doaj   +1 more source

Organ Abnormalities Caused by Turner Syndrome

Cells, 2023
Turner syndrome (TS), a genetic disorder due to incomplete dosage compensation of X-linked genes, affects multiple organ systems, leading to hypogonadotropic hypogonadism, short stature, cardiovascular and vascular abnormalities, liver disease, renal ...
Sang Hoon Yoon, Ga Yeon Kim, Gyu Tae Choi, Jeong Tae Do   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Nature Communications, 2018
DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al.
René Luijk, Haoyu Wu, Cavin K Ward-Caviness, Eilis Hannon, Elena Carnero-Montoro, Josine L. Min, Pooja Mandaviya, Martina Müller-Nurasyid, Hailiang Mei, Silvere M. van der Maarel, BIOS Consortium, Caroline Relton, Jonathan Mill, Melanie Waldenberger, Jordana T. Bell, Rick Jansen, Alexandra Zhernakova, Lude Franke, Peter A. C. ‘t Hoen, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Joyce van Meurs, Lucia Daxinger, P. Eline Slagboom, Erik W. van Zwet, Bastiaan T. Heijmans   +28 more
doaj   +1 more source

Compensation Review Board (CRB) opinions. 2007

, 2007
Updated annually; Began in 2003?; Title from home page last rev. Feb. 6, 2007 (publisher's web site, viewed Mar.
Connecticut. Workers' Compensation Commission. Compensation Review Board.
core   +3 more sources