Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses [PDF]
BMC Biology, 2020 Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to ...
Katherine E. Larrimore +3 more
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Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
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Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome. [PDF]
PLoS Genetics, 2015 The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic variation on the X ...
Michael Stocks +3 more
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X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]
BMC GenomicsBackground X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner +8 more
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Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes [PDF]
BiomoleculesSex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation.
Joshua Eduful +2 more
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The Drosophila over compensating males gene genetically inhibits dosage compensation in males. [PDF]
PLoS ONE, 2013 Male Drosophila are monosomic for the X chromosome, but survive due to dosage compensation. They use the Male Specific Lethal (MSL) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes along the X ∼1.6-1.8 ...
Chiat Koo Lim, Richard L Kelley
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Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. [PDF]
PLoS Genetics, 2012 Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to
Erica Larschan +9 more
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Role of X chromosome and dosage-compensation mechanisms in complex trait genetics [PDF]
The American Journal of Human GeneticsAbstractThe X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated. Here, we systematically assessed the relevance of chrX and the effect of its biology on complex traits
Yu Fu +4 more
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Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]
Nature CommunicationsIn mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei +5 more
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