Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes. [PDF]
PLoS Genetics, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa +2 more
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MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
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Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.
PLoS Genetics, 2023 The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán +3 more
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THE GENETIC BASIS OF DOSAGE COMPENSATION OF ALCOHOL DEHYDROGENASE-1 IN MAIZE [PDF]
Genetics, 1981 ABSTRACT The levels of alcohol dehydrogenase (ADH) do not exhibit a structural gene-dosage effect in a one to four dosage series of the long arm of chromosome one (1L) (BIRCHLER19 79). This phenomenon, termed dosage compensation, has been studied in more detail.
James A Birchler, Birchler James A
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Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. [PDF]
PLoS Genetics, 2012 Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to
Erica Larschan +9 more
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PLoS Genetics, 2012 In Drosophila, the MSL (Male Specific Lethal) complex up regulates transcription of active genes on the single male X-chromosome to equalize gene expression between sexes.
Mahalakshmi Prabhakaran +1 more
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The status of dosage compensation in the multiple X chromosomes of the platypus. [PDF]
PLoS Genetics, 2008 Dosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY males in therian mammals (marsupials ...
Janine E Deakin +3 more
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Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation [PDF]
Genetics, 2010 Abstract Several recent studies have suggested that F1 hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome.
Daniel A Barbash, Barbash Daniel A
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Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly. [PDF]
PLoS ONE, 2015 In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked ...
Rebecca J Linger +2 more
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Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]
Nature CommunicationsIn mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei +5 more
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