Results 21 to 30 of about 38,995 (265)
Dissection of X chromosome dosage compensation for quantitative traits in sheep using different statistical models [PDF]
Scientific ReportsSince males and females have different number of X chromosome, different mechanisms have evolved to equalize dosage of gene products from the X chromosome between XX females and XY males.
Farhad Ghafouri-Kesbi +1 more
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MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
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Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]
PLoS Genetics, 2014 Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott +4 more
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Genetic compensation: A phenomenon in search of mechanisms. [PDF]
PLoS Genetics, 2017 Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals).
Mohamed A El-Brolosy +1 more
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Genetic dosage compensation in a family with velo‐cardio‐facial/DiGeorge/22q11.2 deletion syndrome [PDF]
American Journal of Medical Genetics Part A, 2011 AbstractCytogenetic studies of a male child carrying the 22q11.2 deletion common in patients with velo‐cardio‐facial/DiGeorge syndrome showed an unexpected rearrangement of the 22q11.2 region in his normal appearing mother. The mother carried a 3 Mb deletion on one copy and a reciprocal, similar sized duplication on the other copy of chromosome 22q11.2
Avishai A. Alkalay +6 more
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Computational and Structural Biotechnology Journal, 2020 Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran +3 more
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Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.
PLoS Genetics, 2023 The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán +3 more
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PLoS Genetics, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa +2 more
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The status of dosage compensation in the multiple X chromosomes of the platypus. [PDF]
PLoS Genetics, 2008 Dosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY males in therian mammals (marsupials ...
Janine E Deakin +3 more
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Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R +4 more
core +1 more source