Results 21 to 30 of about 14,179 (253)

Dissection of X chromosome dosage compensation for quantitative traits in sheep using different statistical models

Scientific Reports
Since males and females have different number of X chromosome, different mechanisms have evolved to equalize dosage of gene products from the X chromosome between XX females and XY males.
Farhad Ghafouri-Kesbi, Moradpasha Eskandarinasab   +1 more
doaj   +2 more sources

The effect of X-linked dosage compensation on complex trait variation

Nature Communications, 2019
Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked ...
Julia Sidorenko, Irfahan Kassam, Kathryn E. Kemper, Jian Zeng, Luke R. Lloyd-Jones, Grant W. Montgomery, Greg Gibson, Andres Metspalu, Tonu Esko, Jian Yang, Allan F. McRae, Peter M. Visscher   +11 more
doaj   +2 more sources

Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]

PLoS Genetics, 2014
Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott, Jacqueline E Villalta, Qi Zhou, Doris Bachtrog, Michael B Eisen   +4 more
doaj   +1 more source

Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

Computational and Structural Biotechnology Journal, 2020
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran, Idan Hekselman, Lena Novack, Esti Yeger-Lotem   +3 more
doaj   +1 more source

Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome. [PDF]

PLoS Genetics, 2015
The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic variation on the X ...
Michael Stocks, Rebecca Dean, Björn Rogell, Urban Friberg   +3 more
doaj   +1 more source

Mammalian X chromosome dosage compensation: Perspectives from the germ line

, 2021
Sex chromosomes are advantageous to mammals, allowing them to adopt a genetic rather than environmental sex determination system. However, sex chromosome evolution also carries a burden, because it results in an imbalance in gene dosage between females ...
Mahesh N Sangrithi (8907299), James MA Turner (8273223)   +1 more
core   +1 more source

Targeting determinants of dosage compensation in Drosophila [PDF]

, 2006
The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Rosemarie Lamm, Shelest Vladimir I, Peter B Becker, Gilfillan Gregor D, Becker Peter B, Vladimir I Shelest, Ina K. Dahlsveen, Lamm Rosemarie, Ina K Dahlsveen, Peter B. Becker, Becker, Peter B., Vladimir I. Shelest, Gilfillan, Gregor D., Lamm, Rosemarie, Gregor D Gilfillan, Dahlsveen Ina K, Dahlsveen, Ina K., Shelest, Vladimir I., Gregor D. Gilfillan   +18 more
core   +1 more source

Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression.

PLoS Genetics, 2021
The transformer (tra) gene is essential for female development in many insect species, including the Australian sheep blow fly, Lucilia cuprina. Sex-specific tra RNA splicing is controlled by Sex lethal (Sxl) in Drosophila melanogaster but is auto ...
Megan E Williamson, Ying Yan, Maxwell J Scott   +2 more
doaj   +1 more source

Genetic Analysis of X-Chromosome Dosage Compensation in Caenorhabditis elegans

Genetics, 1987
ABSTRACT We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX).
Meneely, Philip M., Wood, W. B.
openaire   +2 more sources

Single-molecule long-read sequencing reveals the potential impact of posttranscriptional regulation on gene dosage effects on the avian Z chromosome

BMC Genomics, 2022
Background Mammalian sex chromosomes provide dosage compensation, but avian lack a global mechanism of dose compensation. Herein, we employed nanopore sequencing to investigate the genetic basis of gene expression and gene dosage effects in avian Z ...
Jianmei Wang, Yang Xi, Shengchao Ma, Jingjing Qi, Junpeng Li, Rongping Zhang, Chunchun Han, Liang Li, Jiwen Wang, Hehe Liu   +9 more
doaj   +1 more source