Results 21 to 30 of about 2,582,389 (248)

The status of dosage compensation in the multiple X chromosomes of the platypus. [PDF]

PLoS Genetics, 2008
Dosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY males in therian mammals (marsupials ...
Janine E Deakin, Timothy A Hore, Edda Koina, Jennifer A Marshall Graves   +3 more
doaj   +1 more source

Targeting determinants of dosage compensation in Drosophila [PDF]

, 2006
The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Rosemarie Lamm, Shelest Vladimir I, Peter B Becker, Gilfillan Gregor D, Becker Peter B, Vladimir I Shelest, Ina K. Dahlsveen, Lamm Rosemarie, Ina K Dahlsveen, Peter B. Becker, Becker, Peter B., Vladimir I. Shelest, Gilfillan, Gregor D., Lamm, Rosemarie, Gregor D Gilfillan, Dahlsveen Ina K, Dahlsveen, Ina K., Shelest, Vladimir I., Gregor D. Gilfillan   +18 more
core   +2 more sources

THE GENETIC BASIS OF DOSAGE COMPENSATION OF ALCOHOL DEHYDROGENASE-1 IN MAIZE [PDF]

Genetics, 1981
ABSTRACT The levels of alcohol dehydrogenase (ADH) do not exhibit a structural gene-dosage effect in a one to four dosage series of the long arm of chromosome one (1L) (BIRCHLER19 79). This phenomenon, termed dosage compensation, has been studied in more detail.
openaire   +2 more sources

The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex [PDF]

, 2008
Dosage compensation in male Drosophila relies on the X chromosome-specific recruitment of a chromatin-modifying machinery, the dosage compensation complex (DCC). The principles that assure selective targeting of the DCC are unknown.
Grimaud, Charlotte, Peter B Becker, Mitterweger Angelika, Grimaud Charlotte, Becker Peter B., Tobias Straub, Straub, Tobias, Mitterweger, Angelika, Peter B. Becker, Becker, Peter B., Gilfillan Gregor D., Gilfillan, Gregor D., Gregor D Gilfillan, Charlotte Grimaud, Angelika Mitterweger, Gregor D. Gilfillan, Straub Tobias   +16 more
core   +2 more sources

Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression.

PLoS Genetics, 2021
The transformer (tra) gene is essential for female development in many insect species, including the Australian sheep blow fly, Lucilia cuprina. Sex-specific tra RNA splicing is controlled by Sex lethal (Sxl) in Drosophila melanogaster but is auto ...
Megan E Williamson, Ying Yan, Maxwell J Scott   +2 more
doaj   +1 more source

Single-molecule long-read sequencing reveals the potential impact of posttranscriptional regulation on gene dosage effects on the avian Z chromosome

BMC Genomics, 2022
Background Mammalian sex chromosomes provide dosage compensation, but avian lack a global mechanism of dose compensation. Herein, we employed nanopore sequencing to investigate the genetic basis of gene expression and gene dosage effects in avian Z ...
Jianmei Wang, Yang Xi, Shengchao Ma, Jingjing Qi, Junpeng Li, Rongping Zhang, Chunchun Han, Liang Li, Jiwen Wang, Hehe Liu   +9 more
doaj   +1 more source

X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

eLife, 2023
An evolutionary perspective enhances our understanding of biological mechanisms. Comparison of sex determination and X-chromosome dosage compensation mechanisms between the closely related nematode species Caenorhabditis briggsae (Cbr) and Caenorhabditis
Qiming Yang, Te-Wen Lo, Katjuša Brejc, Caitlin Schartner, Edward J Ralston, Denise M Lapidus, Barbara J Meyer   +6 more
doaj   +1 more source

Genetic Analysis of X-Chromosome Dosage Compensation in Caenorhabditis elegans

Genetics, 1987
ABSTRACT We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX).
Meneely, Philip M., Wood, W. B.
openaire   +2 more sources

Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation [PDF]

Genetics, 2010
Abstract Several recent studies have suggested that F1 hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome.
openaire   +2 more sources

Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila.

PLoS Genetics, 2012
In Drosophila, the MSL (Male Specific Lethal) complex up regulates transcription of active genes on the single male X-chromosome to equalize gene expression between sexes.
Mahalakshmi Prabhakaran, Richard L Kelley   +1 more
doaj   +1 more source