Results 11 to 20 of about 1,171,051 (326)

Mechanisms of sex determination and X-chromosome dosage compensation. [PDF]

Genetics, 2022
Abnormalities in chromosome number have the potential to disrupt the balance of gene expression and thereby decrease organismal fitness and viability.
Meyer BJ.
europepmc   +2 more sources

Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis.

PLoS Genetics, 2021
Dosage compensation equalizes X-linked expression between XY males and XX females. In male fruit flies, expression levels of the X-chromosome are increased approximately two-fold to compensate for their single X chromosome. In testis, dosage compensation
Evan Witt, Zhantao Shao, Chun Hu, Henry M Krause, Li Zhao   +4 more
doaj   +2 more sources

Dosage compensation: X-repress yourself [PDF]

Current Biology, 1997
Dosage compensation in Caenorhabditis elegans involves the sex-specific recruitment to the X chromosome of a protein complex, the nature of which suggests that there are mechanistic links between chromosome segregation and global transcriptional ...
Riggs, Cline, Hodgkin, Meyer, Donahue, Rhind, Nonet, Klein, Nusbaum, Hsu, Chuang, Strunnikov, Hirano, Lieb, Chuang, Kellum, Lorentz   +16 more
core   +4 more sources

Dosage Compensation Systems [PDF]

Introduction to Epigenetics, 2021
This chapter provides an introduction to chromosome-wide dosage compensation systems. We will examine the evolution of dosage compensation, which is thought to be driven by the appearance of differentiated sex chromosomes.
R. Paro, U. Grossniklaus, R. Santoro, A. Wutz   +3 more
semanticscholar   +2 more sources

Modulation of transcription burst amplitude underpins dosage compensation in theDrosophilaembryo

bioRxiv, 2023
Dosage compensation, the balancing of X linked gene expression between sexes and to the autosomes, is critical to an organism’s fitness and survival. In Drosophila, dosage compensation involves hypertranscription of the male X chromosome.
Forbes Beadle L, Zhou H, Rattray M, Ashe HL.   +3 more
europepmc   +2 more sources

Dosage Compensation in Drosophila: Its Canonical and Non-Canonical Mechanisms. [PDF]

Int J Mol Sci, 2022
Dosage compensation equalizes gene expression in a single male X chromosome with that in the pairs of autosomes and female X chromosomes. In the fruit fly Drosophila, canonical dosage compensation is implemented by the male-specific lethal (MSL) complex ...
Shevelyov YY, Ulianov SV, Gelfand MS, Belyakin SN, Razin SV.   +4 more
europepmc   +2 more sources

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

iScience, 2021
Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L. Arias-Arias, Luis A. Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez   +16 more
doaj   +2 more sources

Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype [PDF]

BMC Genomics
Background Lizards have sex determination systems that can differ between even closely related species. These include XY and ZW systems, and thermolabile systems where genes and temperature interact to determine sex.
Benjamin J. Hanrahan, J King Chang, Ashley M. Milton, Nicholas C. Lister, Duminda S. B. Dissanayake, Jillian M. Hammond, Andre L. M. Reis, Ira W. Deveson, Aurora Ruiz-Herrera, Hardip R. Patel, Jennifer A. Marshall Graves, Arthur Georges, Paul D. Waters   +12 more
doaj   +2 more sources

Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates [PDF]

Nature Communications
Sex-chromosome dosage poses a challenge for heterogametic species in maintaining the proper balance of gene products across chromosomes in each sex.
Natali Papanicolaou, Antonio Lentini, Sebastian Wettersten, Michael Hagemann-Jensen, Annika Krüger, Jilin Zhang, Christos Coucoravas, Ioannis Petrosian, Xian Xin, Ilhan Ceyhan, Joanna Rorbach, Dominic Wright, Björn Reinius   +12 more
doaj   +2 more sources

Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]

Nature Communications
In mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei, Barry Kesner, Uri Weissbein, Peera Wasserzug-Pash, Priyojit Das, Jeannie T. Lee   +5 more
doaj   +2 more sources