Results 11 to 20 of about 30,369 (277)
Targeting determinants of dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2006 The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Ina K Dahlsveen +4 more
doaj +8 more sources
Dosage compensation in birds [PDF]
Current Biology, 2001 The Z and W sex chromosomes of birds have evolved independently from the mammalian X and Y chromosomes [1]. Unlike mammals, female birds are heterogametic (ZW), while males are homogametic (ZZ). Therefore male birds, like female mammals, carry a double dose of sex-linked genes relative to the other sex.
McQueen, Heather A +4 more
core +5 more sources
Epigenetics & Chromatin, 2018 Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
doaj +2 more sources
Global analysis of X-chromosome dosage compensation
Journal of Biology, 2006 Background Drosophila melanogaster females have two X chromosomes and two autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA).
Malley James D +8 more
doaj +2 more sources
DOSAGE COMPENSATION: REGULATION OF SEX CHROMOSOME GENE EXPRESSION
Вавиловский журнал генетики и селекции, 2014 Dosage compensation is observed in various taxa of organisms with heteromorphic sex chromosomes. Dosage compensation mechanisms are thought to have arisen to eliminate differences in gene dosage between sexes that appeared in the course of sex chromosome
E. V. Dementyeva
doaj +1 more source
General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq [PDF]
BMC Genomics, 2011 Background Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to ...
Wolf Jochen BW, Bryk Jarosław
doaj +2 more sources
A Synthetic Sponge System Against miRNAs of the miR-17/92 Cluster Targets Transcriptional MYC Dosage Compensation in Aneuploid Cancer [PDF]
CellsBackground: Genomic instability, a hallmark of cancer, leads to copy number variations disrupting gene dosage balance and contributing to tumor progression.
Diana M. Bravo-Estupiñan +9 more
doaj +2 more sources
Dosage compensation is less effective in birds than in mammals [PDF]
Journal of Biology, 2007 Background In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved to effectively balance the expressed dose of X-linked genes ...
Itoh Yuichiro +12 more
doaj +2 more sources
Compensation of gene dosage on the mammalian X [PDF]
DevelopmentABSTRACT Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they can also lead to gene dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring gene dosage differences and their compensation.
Daniela Cecalev +2 more
openaire +3 more sources
The sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes [PDF]
Nature, 2023 Agata Kalita +2 more
exaly +2 more sources