Results 31 to 40 of about 30,369 (277)
Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
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Frontiers in Genetics, 2021 How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai +4 more
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Nuclear Organization and Dosage Compensation [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Dosage compensation is a strategy to deal with the imbalance of sex chromosomal gene products relative to autosomes and also between the sexes. The mechanisms that ensure dosage compensation for X-chromosome activity have been extensively studied in mammals, worms, and flies.
Jennifer C, Chow, Edith, Heard
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Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development
Cell Reports, 2019 Summary: Dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a model for how genes are targeted for coordinated regulation.
Leila Elizabeth Rieder +2 more
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
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Dosage Compensation inDrosophila [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X.
John C, Lucchesi, Mitzi I, Kuroda
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The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex [PDF]
, 2008 Dosage compensation in male Drosophila relies on the X chromosome-specific recruitment of a chromatin-modifying machinery, the dosage compensation complex (DCC). The principles that assure selective targeting of the DCC are unknown.
Grimaud, Charlotte +16 more
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Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation. [PDF]
Proc Natl Acad Sci U S AHeteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates.
Lister NC +16 more
europepmc +3 more sources
SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2008 In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome.
Anne Spierer +3 more
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Pluripotent cells will not dosage compensate [PDF]
Worm, 2014 Dosage compensation is the mechanism that balances gene expression levels between males and females as well as between the X chromosome and autosomes. In mammals, loss of pluripotency and differentiation are closely linked with the onset of dosage compensation. Pluripotency factors negatively regulate Xist (the non-coding RNA that triggers X chromosome
Jianhao, Jiang +2 more
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