Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation [PDF]
, 2012 Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to
Bishop, Eric +9 more
core +8 more sources
Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage [PDF]
, 2017 Sex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages. Here, we trace the functional evolution of the XY Chromosomes of the green anole lizard (Anolis carolinensis), on the basis of extensive high-throughput ...
Brüning, T +15 more
core +3 more sources
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila
Life Science Alliance, 2021 CRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
C. I. Keller Valsecchi +4 more
semanticscholar +1 more source
Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues [PDF]
PeerJ, 2015 In Drosophila melanogaster, the male-specific lethal (MSL) complex has been studied extensively for its role in upregulating male X-linked genes. Recent advances in high-throughput technologies have improved our understanding of how the MSL complex ...
Steven P. Vensko II, Eric A. Stone
doaj +2 more sources
Stem Cell Reports, 2021 Summary Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug discovery and the development of cell-based therapies. However, the long non-coding RNA XIST, which is essential for the establishment and maintenance of X ...
A. Fukuda +14 more
semanticscholar +1 more source
An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure? [PDF]
, 2010 Background X chromosomes are subject to dosage compensation in Drosophila males. Dosage compensation requires cis sequence features of the X chromosome that are present in both sexes by definition and trans acting factors that target chromatin modifying ...
Yu Zhang, Brian Oliver
core +1 more source
The C. elegans dosage compensation complex mediates interphase X chromosome compaction [PDF]
, 2014 Background Dosage compensation is a specialized gene regulatory mechanism which equalizes X-linked gene expression between sexes. In Caenorhabditis elegans, dosage compensation is achieved by the activity of the dosage compensation ...
Csankovszki, Györgyi +2 more
core +1 more source
Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
semanticscholar +1 more source
Genome biology, 2007 How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.
Deng, Xinxian, Disteche, Christine M
openaire +2 more sources