Results 51 to 60 of about 30,395 (278)

Masc‐induced dosage compensation in silkworm cultured cells

FEBS Open Bio, 2019
The Masculinizer (Masc) gene encodes a CCCH‐tandem zinc finger protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori.
Susumu Katsuma, Keisuke Shoji, Yudai Sugano, Yutaka Suzuki, Takashi Kiuchi   +4 more
doaj   +1 more source

Decoding dosage compensation.

Genome biology, 2007
How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.
Deng, Xinxian, Disteche, Christine M
openaire   +2 more sources

Novel Roles for Heterochromatin and Nuclear RNAi in C. elegans Dosage Compensation [PDF]

, 2021
Dosage compensation involves chromosome-wide gene regulatory mechanisms which impact higher order chromatin structure and are crucial for organismal health. Dosage compensation in C.
Davis, Michael
core   +1 more source

Abnormal dosage compensation of reporter genes driven by the Drosophila glass multiple reporter (GMR) enhancer-promoter. [PDF]

PLoS ONE, 2011
In Drosophila melanogaster the male specific lethal (MSL) complex is required for upregulation of expression of most X-linked genes in males, thereby achieving X chromosome dosage compensation.
Corey Laverty, Fang Li, Esther J Belikoff, Maxwell J Scott   +3 more
doaj   +1 more source

Partial Dosage Compensation in Strepsiptera, a Sister Group of Beetles [PDF]

, 2015
Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Mahajan, Shivani, Bachtrog, Doris
core   +1 more source

Variable dosage compensation is associated with female consequences of an X-linked, male-beneficial mutation [PDF]

, 2021
Funding:TJH was supported by a PhD studentship from the University of St Andrews School of Biology. The study received funding from the UK Natural Environment Research Council to NWB and JGR (NE/T0006191/1) and NWB (NE/L011255/1, NE/I027800/1).Recent ...
Thomas J. Hitchcock, Hitchcock, Thomas, Jack G. Rayner, Bailey, Nathan William, Nathan W. Bailey, Rayner, Jack Gregory   +5 more
core   +1 more source

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

iScience, 2021
Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L. Arias-Arias, Luis A. Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez   +16 more
doaj   +1 more source

Translating dosage compensation to trisomy 21 [PDF]

Nature, 2013
Down's syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance across an extra chromosome can be de facto corrected by manipulating a single gene, XIST (the X-inactivation gene).
Jiang, Jun, Jing, Yuanchun, Cost, Gregory J., Chiang, Jen-Chieh, Kolpa, Heather J., Cotton, Allison M., Carone, Dawn M., Carone, Benjamin R., Shivak, David A., Guschin, Dmitry Y., Pearl, Jocelynn R., Rebar, Edward J., Byron, Meg, Gregory, Philip D., Brown, Carolyn J., Urnov, Fyodor D., Hall, Lisa L., Lawrence, Jeanne B.   +17 more
openaire   +4 more sources

Compensation of dosage-sensitive genes on the chicken Z chromosome [PDF]

, 2016
In many diploid species, sex determination is linked to a pair of sex chromosomes that evolved from a pair of autosomes. In these organisms, the degeneration of the sex-limited Y or W chromosome causes a reduction in gene dose in the heterogametic sex ...
Dessimoz, C., Zimmer, F, Mank, JE, Zimmer, F., Harrison, P.W., Mank, J.E., Harrison, PW, Dessimoz, C   +7 more
core   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source