Results 71 to 80 of about 1,171,051 (326)
Current Opinion in Cell Biology, 2000 Recent advances in our understanding of dosage compensation in flies have centered on characterizing its sex-specificity, identifying the structural RNAs involved in the process, and determining how dosage compensation is targeted to particular sites on the X chromosome.
A, Franke, B S, Baker
openaire +2 more sources
Translating dosage compensation to trisomy 21 [PDF]
Nature, 2013 Down's syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance across an extra chromosome can be de facto corrected by manipulating a single gene, XIST (the X-inactivation gene).
Jiang, Jun +17 more
openaire +4 more sources
Sex Chromosome Dosage Compensation in Heliconius Butterflies: Global yet Still Incomplete? [PDF]
, 2015 The evolution of heterogametic sex chromosomes is often-but not always-accompanied by the evolution of dosage compensating mechanisms that mitigate the impact of sex-specific gene dosage on levels of gene expression.
Hardcastle, Thomas J +2 more
core +3 more sources
Targeting determinants of dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2006 The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Ina K Dahlsveen +4 more
doaj +2 more sources
A General Mechanism for Network-Dosage Compensation in Gene Circuits [PDF]
, 2010 Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation.
Acar, Murat +4 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]
PLoS Genetics, 2008 X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston +5 more
doaj +1 more source
Compensation of gene dosage on the mammalian X
DevelopmentChanges in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they can also lead to gene dysregulation and pathologies.
Daniela Cecalev +2 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos
Scientific Reports, 2021 Dosage compensation is a mechanism that equalizes sex chromosome gene expression between the sexes. In Drosophila, individuals with two X chromosomes (XX) become female, whereas males have one X chromosome (XY).
Ryoma Ota +4 more
doaj +1 more source