Results 81 to 90 of about 30,395 (278)
PLoS Genetics, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Heterochromatin formation and dosage compensation. [PDF]
, 2013 (A) Sliding window enrichment profile of H3K9me2-enrichment along neo-Y genes, and H4K16ac and MSL-binding along their neo-X homologs. (B) H4K16ac-enrichment of neo-X genes versus H3K9me2-enrichment at their neo-Y homologs.
Doris Bachtrog (1163) +5 more
core +1 more source
Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
Nature Communications, 2019 In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C ...
Koustav Pal +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Cells, 2020 Chromosome-specific regulatory mechanisms provide a model to understand the coordinated regulation of genes on entire chromosomes or on larger genomic regions. In fruit flies, two chromosome-wide systems have been characterized: The male-specific lethal (
Samaneh Ekhteraei-Tousi +2 more
doaj +1 more source
The effect of hybridization on dosage compensation in member species of the Anopheles gambiae species complex [PDF]
, 2018 Dosage compensation has evolved in concert with Y-chromosome degeneration in many taxa that exhibit heterogametic sex chromosomes. Dosage compensation overcomes the biological challenge of a "half dose" of X chromosome gene transcripts in the ...
Takken, Willem +2 more
core +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
How do heterogametic females survive without gene dosage compensation? [PDF]
, 1991 When the male is the heterogametic sex (XX-XY or XX-XO), as inDrosophila, orthopteran insects, mammals andCaenorhabditis elegans, X-linked genes are subject to dosage compensation: the single X in the male is functionally equivalent to the two Xs in the ...
Sharat Chandra, H.
core +1 more source
Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning
Molecular Systems BiologyAneuploidy, a hallmark of cancer, alters chromosome copy numbers and with that the abundance of hundreds of proteins. Evidence suggests that levels of proteins encoded on affected chromosomes are often buffered toward their abundances observed in ...
Erik Marcel Heller +5 more
doaj +1 more source