Results 101 to 110 of about 30,395 (278)

Evolutionary Comparison of X-Chromosome Dosage Compensation Across Caenorhabditis Species [PDF]

, 2016
Many species determine sex by assessing sex-chromosome dose. In flies, mammals, and nematodes, males have one X chromosome and females or hermaphrodites have two.
Schartner, Caitlin Marie
core  

Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

Computational and Structural Biotechnology Journal, 2020
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran, Idan Hekselman, Lena Novack, Esti Yeger-Lotem   +3 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Dosage compensation of sex- and autosomal chromosomes [PDF]

Gene dosage imbalances that arise from imbalanced chromosome copy numbers (aneuploidy) are disruptive to organismal fitness and homeostasis. An exception to that can be found in the case of heteromorphic sex chromosome systems such as the mammalian XX/XY
Natali Papanicolaou (18683899)
core   +1 more source

Modeling Down Syndrome Neurodevelopment with Dosage Compensation [PDF]

, 2019
Due to their underlying genetic complexity, chromosomal disorders such as Down syndrome (DS), which is caused by trisomy 21, have long been understudied and continue to lack effective treatments.
Czerminski, Jan T.
core   +2 more sources

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Data from: Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta [PDF]

, 2014
Sex chromosome dosage compensation balances homogametic sex chromosome expression with autosomal expression in the heterogametic sex, leading to sex chromosome expression parity between the sexes. If compensation is incomplete this can lead to expression
Briscoe, Adriana D., Bissard, Gary W., Blissard, Gary W, Chen, Yun-Ru, Briscoe, Adriana D, Smith, Gilbert   +5 more
core   +1 more source

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development.

PLoS Genetics
Differentiated sex chromosomes are frequently associated with major transcriptional changes: the evolution of dosage compensation (DC) to equalize gene expression between the sexes and the establishment of meiotic sex chromosome inactivation (MSCI).
Jelisaveta Djordjevic, Patrick Tran Van, William Toubiana, Marjorie Labédan, Zoé Dumas, Jean-Marc Aury, Corinne Cruaud, Benjamin Istace, Karine Labadie, Benjamin Noel, Darren J Parker, Tanja Schwander   +11 more
doaj   +1 more source

Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos

BMC Genomics, 2010
Background Considerable progress has been made in our understanding of sex determination and dosage compensation mechanisms in model organisms such as C. elegans, Drosophila and M. musculus.
Mathur Sachin, Zhang Shaobing O, Hattem Gaye, Tassy Olivier, Pourquié Olivier   +4 more
doaj   +1 more source

Dosage compensation for the birds [PDF]

Heredity, 2009
S ex chromosomes evolve from a homologous pair of chromosomes to become cytologically distinct. Consequently, fertilization produces one of two different chromosomal combinations that will initiate either the male or female developmental program.
openaire   +1 more source