Results 91 to 100 of about 30,369 (277)

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels

Nature Communications
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes.
Ryan N. Allsop, Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Suresh Poovanthingal, Wilfred F. J. van IJcken, Jeroen A. A. Demmers, Hegias Mira Bontenbal, Cristina Gontan, Joost Gribnau, Vincent Pasque   +10 more
doaj   +1 more source

Dosage compensation rox!

Current Opinion in Cell Biology, 2000
Recent advances in our understanding of dosage compensation in flies have centered on characterizing its sex-specificity, identifying the structural RNAs involved in the process, and determining how dosage compensation is targeted to particular sites on the X chromosome.
A, Franke, B S, Baker
openaire   +2 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Evolutionary Comparison of X-Chromosome Dosage Compensation Across Caenorhabditis Species [PDF]

, 2016
Many species determine sex by assessing sex-chromosome dose. In flies, mammals, and nematodes, males have one X chromosome and females or hermaphrodites have two.
Schartner, Caitlin Marie
core  

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

Computational and Structural Biotechnology Journal, 2020
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran, Idan Hekselman, Lena Novack, Esti Yeger-Lotem   +3 more
doaj   +1 more source

Electrode and Microstructure Dependence of Oxygen Diffusion in Ferroelectric Hafnium Zirconium Oxide Thin Films

Advanced Functional Materials, EarlyView.
Significant nanoscale oxygen diffusion coefficient variations are measured in ferroelectric hafnium zirconium oxide films with grain boundaries and electrode interfaces exhibiting values 104 times larger than the grain cores. Overall coefficients are 10X larger for films prepared with metal nitride electrodes compared to refractory metals. New insights
Liron Shvilberg, Thomas W. Pfeifer, Chuanzhen Zhou, Yong Kyu Choi, Duk‐Hyun Choe, Patrick E. Hopkins, Jon F. Ihlefeld   +6 more
wiley   +1 more source

Data from: Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta [PDF]

, 2014
Sex chromosome dosage compensation balances homogametic sex chromosome expression with autosomal expression in the heterogametic sex, leading to sex chromosome expression parity between the sexes. If compensation is incomplete this can lead to expression
Briscoe, Adriana D., Bissard, Gary W., Blissard, Gary W, Chen, Yun-Ru, Briscoe, Adriana D, Smith, Gilbert   +5 more
core   +1 more source

Integrated Field‐Free SOT Domain‐Wall Synapses and MTJ Stochastic Neurons for Hardware Boltzmann Machines

Advanced Functional Materials, EarlyView.
Field‐free spin‐orbit torque domain‐wall synapses integrated with stochastic MTJ neurons enable compact hardware Boltzmann machines. Leveraging intrinsic stochasticity and multi‐level conductance, the system achieves efficient probabilistic learning with high accuracy, demonstrating a scalable spintronic platform for energy‐efficient edge AI.
Aijaz H. Lone, Meng Tang, Camelia Florica, Bin He, Jingkai Xu, Selma Amara, Georgian Melinte, Xixiang Zhang, Gianluca Setti   +8 more
wiley   +1 more source

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development.

PLoS Genetics
Differentiated sex chromosomes are frequently associated with major transcriptional changes: the evolution of dosage compensation (DC) to equalize gene expression between the sexes and the establishment of meiotic sex chromosome inactivation (MSCI).
Jelisaveta Djordjevic, Patrick Tran Van, William Toubiana, Marjorie Labédan, Zoé Dumas, Jean-Marc Aury, Corinne Cruaud, Benjamin Istace, Karine Labadie, Benjamin Noel, Darren J Parker, Tanja Schwander   +11 more
doaj   +1 more source