Results 121 to 130 of about 30,369 (277)
Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues
, 2019 Dosage compensation of the mammalian X chromosome (X) was proposed by Susumu Ohno as a mechanism wherein the inactivation of one X in females would lead to doubling the expression of the other.
Jiang, Zongliang
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Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes
BMC Biology, 2007 Background The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes.
Kultima Kim +5 more
doaj +1 more source
Non-canonical and sexually dimorphic X dosage compensation states in the mouse and human germline [PDF]
, 2016 Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances X gene with autosomal gene output.
Mahadevaiah, SK +8 more
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Advanced Materials, EarlyView.Ultrathin lithium metal anodes (≤15 µm) offer a promising route to high‐energy‐density batteries due to their high capacity and low potential. This review presents design principles for ultrathin Li, evaluates fabrication strategies, and discusses challenges in liquid and solid‐state cells.
Cheng Wang +9 more
wiley +1 more source
Dosage compensation can buffer copy- number variation in wild yeast [PDF]
, 2020 Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy,
Chris Mun Yong +5 more
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Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles
Advanced Materials, EarlyView.This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen +19 more
wiley +1 more source
Advanced Materials, EarlyView.This work presents soft, degradable hydrogel microcarriers that combine magnetic responsiveness with the ability to host multiple therapeutic and cellular components. Produced by droplet microfluidics, the carriers maintain structural integrity during manipulation, permit controlled breakdown under physiological conditions, and enable guided motion for
Xuan Peng +18 more
wiley +1 more source
Dosage compensation of sex- and autosomal chromosomes
Gene dosage imbalances that arise from imbalanced chromosome copy numbers (aneuploidy) are disruptive to organismal fitness and homeostasis. An exception to that can be found in the case of heteromorphic sex chromosome systems such as the mammalian XX/XY
Natali Papanicolaou (18683899)
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Modeling Down Syndrome Neurodevelopment with Dosage Compensation
, 2019 Due to their underlying genetic complexity, chromosomal disorders such as Down syndrome (DS), which is caused by trisomy 21, have long been understudied and continue to lack effective treatments.
Czerminski, Jan T.
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Advanced Materials Interfaces, EarlyView.BioEISense is a microfluidic device with integrated impedance sensors, for real‐time, label‐free monitoring of S. aureus biofilms. In this study, the biofilm culture conditions were optimized to support sensitive and reproducible detection of biofilm formation and eradication under dynamic flow‐through conditions. The system was also validated for both
Jéssica Amorim +6 more
wiley +1 more source