Results 121 to 130 of about 1,171,051 (326)

Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning

Molecular Systems Biology
Aneuploidy, a hallmark of cancer, alters chromosome copy numbers and with that the abundance of hundreds of proteins. Evidence suggests that levels of proteins encoded on affected chromosomes are often buffered toward their abundances observed in ...
Erik Marcel Heller, Karen Barthel, Markus Räschle, Klaske M Schukken, Jason M Sheltzer, Zuzana Storchová   +5 more
doaj   +1 more source

Infrared Nanocrystals for Space Application: Hardness to Irradiations

Advanced Functional Materials, EarlyView.
This article investigates infrared HgTe nanocrystals under X‐ray and ion irradiation, revealing remarkable radiation hardness. It uncovers distinct degradation mechanisms and shows that the nanomaterial outperforms integrated electronics. The results position colloidal nanocrystals as promising candidates for resilient space and harsh‐environment ...
Alexandre Neyret, Dario Mastrippolito, Bingbing Xia, Adrien Khalili, Maxime Lebreton, Giorgia Strobbia, Albin Colle, Marco Paye, Mariarosa Cavallo, Erwan Bossavit, Claire Abadie, Yoann Prado, Debora Pierucci, Victor Parahyba, Francois Coursaget, David Darson, Emrick Briand, Ian Vickridge, Stephane Demiguel, Sebastien Massenot, Jean‐Marc Belloir, Vincent Goiffon, Emmanuel Lhuillier   +22 more
wiley   +1 more source

X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies

BMC Genomics
Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi   +8 more
doaj   +1 more source

Expression of homoeologous molecular systems in wheat alloploids [PDF]

, 1976
Allopolyploidy is widespread in the plant kingdom, where it has been of considerable evolutionary significance. Although the existence of heterotic interactions between the genomes that make up an alloploid have been generally assumed, the precise nature
Aragoncillo Ballesteros, Cipriano, Carbonero Zalduegui, Pilar, Fernandez de Caleya, R., García Olmedo, Francisco, Torres, V.   +4 more
core   +1 more source

Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.)

, 1978
Gene-dosage responses for a group of six wheat endosperm proteins have been investigated by using compensated nulli-tetrasomic lines of cv. Chinese Spring. Practically linear dosage responses have been observed for all the proteins.
Aragoncillo Ballesteros, Cipriano, Rodriguez Loperena, M.A., Salcedo Duran, Gabriel, Carbonero Zalduegui, Pilar, García Olmedo, Francisco   +4 more
core   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels

Nature Communications
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes.
Ryan N. Allsop, Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Suresh Poovanthingal, Wilfred F. J. van IJcken, Jeroen A. A. Demmers, Hegias Mira Bontenbal, Cristina Gontan, Joost Gribnau, Vincent Pasque   +10 more
doaj   +1 more source

Quality of life with ivabradine in patients with angina pectoris [PDF]

, 2016
Background—To explore the effect of ivabradine on angina-related quality of life (QoL) in patients participating in the Study Assessing the Morbidity–Mortality Benefits of the If Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) QoL
Chassany, Olivier, Ferrari, Roberto, Ford, Ian, Fox, Kim, Steg, Philippe Gabriel, Tardif, Jean-Claude, Tendera, Michal   +6 more
core   +1 more source

Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Morphologically and functionally distinct X and Y chromosomes have repeatedly evolved across the tree of life. However, the extent of differentiation between the sex chromosomes varies substantially across species. As sex chromosomes diverge,
I. Darolti, Alison E. Wright, B. Sandkam, Jake Morris, Natasha I. Bloch, M. Farré, R. Fuller, G. Bourne, D. Larkin, F. Breden, J. Mank   +10 more
semanticscholar   +1 more source

Liquid Phase Transmission Electron Microscopy: A Window into the Early Stages of Complex Material Formation

Advanced Functional Materials, EarlyView.
Liquid‐phase transmission electron microscopy enables direct observation of nucleation and growth processes in solution. This review is dedicated to the remembrance of Helmut Cölfen and highlights recent studies on complex materials—oxides, biominerals, organic–inorganic crystals—which were central to his research activity. It summarizes key milestones,
Charles Sidhoum, Vinavadini Ramnarain, Nathaly Ortiz Peña, Dris Ihiawakrim, Clément Sanchez, Ovidiu Ersen   +5 more
wiley   +1 more source