The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex. [PDF]
PLoS Genetics, 2008 Dosage compensation in male Drosophila relies on the X chromosome-specific recruitment of a chromatin-modifying machinery, the dosage compensation complex (DCC). The principles that assure selective targeting of the DCC are unknown.
Tobias Straub +4 more
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Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1. [PDF]
PLoS Genetics, 2009 Dosage compensation ensures similar levels of X-linked gene products in males (XY or XO) and females (XX), despite their different numbers of X chromosomes.
Emily L Petty +4 more
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Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex in Drosophila melanogaster and Its Association With Transcription Divergence [PDF]
Frontiers in Genetics, 2021 How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai +4 more
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Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome [PDF]
Cell Reports, 2018 Summary: Little is known about how variation in sequence composition alters transcription factor occupancy to precisely recruit large transcription complexes. A key model for understanding how transcription complexes are targeted is the Drosophila dosage
Emily G. Kaye +7 more
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A sequence motif enriched in regions bound by the
BMC Genomics, 2010 Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood.
Aldecoa Rodrigo +3 more
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The effect of X-linked dosage compensation on complex trait variation [PDF]
Nature Communications, 2019 Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked ...
Julia Sidorenko +11 more
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X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males.
PLoS Biology, 2004 It has been proposed that dosage compensation in Drosophila males occurs by binding of two core proteins, MSL-1 and MSL-2, to a set of 35-40 X chromosome "entry sites" that serve to nucleate mature complexes, termed compensasomes, which then spread to ...
Delphine Fagegaltier, Bruce S Baker
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Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes [PDF]
BiomoleculesSex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation.
Joshua Eduful +2 more
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Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning [PDF]
Molecular Systems BiologyAneuploidy, a hallmark of cancer, alters chromosome copy numbers and with that the abundance of hundreds of proteins. Evidence suggests that levels of proteins encoded on affected chromosomes are often buffered toward their abundances observed in ...
Erik Marcel Heller +5 more
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X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]
BMC GenomicsBackground X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner +8 more
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