Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos
Scientific Reports, 2021 Dosage compensation is a mechanism that equalizes sex chromosome gene expression between the sexes. In Drosophila, individuals with two X chromosomes (XX) become female, whereas males have one X chromosome (XY).
Ryoma Ota +4 more
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Functional integration of the histone acetyltransferase MOF into the dosage compensation complex [PDF]
The EMBO Journal, 2004 Dosage compensation in flies involves doubling the transcription of genes on the single male X chromosome to match the combined expression level of the two female X chromosomes. Crucial for this activation is the acetylation of histone H4 by the histone acetyltransferase (HAT) MOF.
Violette, Morales +5 more
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Drosophiladosage compensation: a complex voyage to the X chromosome [PDF]
Development, 2009 Dosage compensation is the crucial process that equalizes gene expression from the X chromosome between males (XY) and females (XX). In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating transcription from the single male X chromosome approximately twofold.
Marnie E, Gelbart, Mitzi I, Kuroda
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The dosage compensation complex shapes the conformation of the X chromosome in Drosophila. [PDF]
Genes Dev, 2009 The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1–MSL2 are responsible for this male-
Grimaud C, Becker PB.
europepmc +4 more sources
Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development
Cell Reports, 2019 Summary: Dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a model for how genes are targeted for coordinated regulation.
Leila Elizabeth Rieder +2 more
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Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation. [PDF]
PLoS Genetics, 2016 Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression.
Guray Kuzu +14 more
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Targeting determinants of dosage compensation in Drosophila [PDF]
, 2006 The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Rosemarie Lamm +18 more
core +2 more sources
The MRG Domain Mediates the Functional Integration of MSL3 into the Dosage Compensation Complex [PDF]
Molecular and Cellular Biology, 2005 The male-specific-lethal (MSL) proteins in Drosophila melanogaster serve to adjust gene expression levels in male flies containing a single X chromosome to equal those in females with a double dose of X-linked genes. Together with noncoding roX RNA, MSL proteins form the "dosage compensation complex" (DCC), which interacts selectively with the X ...
Violette, Morales +4 more
openaire +2 more sources
Dosage compensation in birds [PDF]
, 2001 The Z and W sex chromosomes of birds have evolved independently from the mammalian X and Y chromosomes [1]. Unlike mammals, female birds are heterogametic (ZW), while males are homogametic (ZZ).
Bird, Adrian P +14 more
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MOF-Regulated Acetylation of MSL-3 in the Drosophila Dosage Compensation Complex [PDF]
Molecular Cell, 2003 Dosage compensation ensures equal expression of X-linked genes in males and females. In Drosophila, equalization is achieved by hypertranscription of the male X chromosome. This process requires an RNA/protein containing dosage compensation complex (DCC).
Buscaino, Alessia +7 more
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