Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. [PDF]
PLoS Genetics, 2012 Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to
Erica Larschan +9 more
doaj +6 more sources
Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
doaj +4 more sources
Noncoding roX RNA remodeling triggers fly dosage compensation complex assembly. [PDF]
Molecular Cell, 2013 Spreading of dosage compensation over the X chromosome in Drosophila males requires the noncoding roX1 and roX2 RNAs. In this issue, Ilik et al. (2013) and Maenner et al.
Wutz A
core +4 more sources
Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation. [PDF]
EMBO Rep, 2017 X chromosome dosage compensation in Drosophila requires chromosome-wide coordination of gene activation. The male-specific lethal dosage compensation complex (DCC) identifies and binds to X-chromosomal high-affinity sites (HAS) from which it boosts transcription. A sub-class of HAS, PionX sites, represent first contacts on the X.
Schauer T +7 more
europepmc +4 more sources
The C. elegans dosage compensation complex mediates interphase X chromosome compaction. [PDF]
Epigenetics Chromatin, 2014 Dosage compensation is a specialized gene regulatory mechanism which equalizes X-linked gene expression between sexes. In Caenorhabditis elegans, dosage compensation is achieved by the activity of the dosage compensation complex (DCC). The DCC localizes to both X chromosomes in hermaphrodites to downregulate gene expression by half.
Lau AC, Nabeshima K, Csankovszki G.
europepmc +5 more sources
, 2010 2010, 1st quarter-; At head of title: Ohio Deferred Compensation.; "A publication of the Ohio Deferred Compensation Board.
core +13 more sources
X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues [PDF]
PeerJ, 2015 In Drosophila melanogaster, the male-specific lethal (MSL) complex has been studied extensively for its role in upregulating male X-linked genes. Recent advances in high-throughput technologies have improved our understanding of how the MSL complex ...
Steven P. Vensko II, Eric A. Stone
doaj +2 more sources
No evidence for a global male-specific lethal complex-mediated dosage compensation contribution to the demasculinization of the Drosophila melanogaster X chromosome. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster males, the expression of X-linked genes is regulated by mechanisms that operate on a chromosomal scale. One such mechanism, male-specific lethal complex-dependent X-linked dosage compensation, is thought to broadly enhance the ...
Steven P Vensko, Eric A Stone
doaj +1 more source
The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
doaj +1 more source
Abnormal dosage compensation of reporter genes driven by the Drosophila glass multiple reporter (GMR) enhancer-promoter. [PDF]
PLoS ONE, 2011 In Drosophila melanogaster the male specific lethal (MSL) complex is required for upregulation of expression of most X-linked genes in males, thereby achieving X chromosome dosage compensation.
Corey Laverty +3 more
doaj +1 more source