Results 31 to 40 of about 5,790,672 (267)
General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq [PDF]
, 2011 Background Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to ...
Bryk, Jaroslaw, +11 more
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Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes [PDF]
Genes & Development, 2007 Dosage compensation is a process required to balance the expression of X-linked genes between males and females. In Drosophila this is achieved by targeting the dosage compensation complex or the male-specific lethal (MSL) complex to the male X chromosome.
Jop, Kind, Asifa, Akhtar
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SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2008 In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome.
Anne Spierer +3 more
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Global Analysis of the Relationship between JIL-1 Kinase and Transcription [PDF]
, 2010 The ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation has remained controversial.
Regnard Catherine +20 more
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Computational and Structural Biotechnology Journal, 2020 Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran +3 more
doaj +1 more source
Epigenetics & Chromatin, 2018 Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
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Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions. [PDF]
PLoS Genetics, 2014 Long non-coding RNAs contribute to dosage compensation in both mammals and Drosophila by inducing changes in the chromatin structure of the X-chromosome.
Margarida L A Figueiredo +5 more
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Modulation of transcription burst amplitude underpins dosage compensation in the Drosophila embryo
Cell Reports, 2023 Summary: Dosage compensation, the balancing of X-linked gene expression between sexes and to the autosomes, is critical to an organism’s fitness and survival. In Drosophila, dosage compensation involves hypertranscription of the male X chromosome.
Lauren Forbes Beadle +3 more
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ARCHITECTURE OF DROSOPHILA DOSAGE COMPENSATION COMPLEX [PDF]
, 2012 In heterogametic organisms, male and female cells harbor structurally different sex chromosome pairs. The difference in the transcriptional output of these sex chromosomes is epigenetically balanced, a phenomenon dubbed as dosage compensation. In Drosophila, male cells up-regulate their one X chromosome roughly two times by the help of a molecular ...
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Distinct Dosage Compensation Effects by Subunits of Drosophila MSL Complexes [PDF]
Biophysical Journal, 2013 Epigenetic regulation at the chromosomal level compensates for the difference in the dosage of X-linked genes between the sexes (dosage compensation). In Drosophila, this regulatory mechanism operates through the MSL complex that enhances the transcription of many genes on the X chromosome in males.
Dunlap, David D. +6 more
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