Results 41 to 50 of about 5,790,672 (267)
Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels. [PDF]
PLoS ONE, 2011 Dosage compensation is a specialized form of gene regulation that balances sex-chromosome linked gene expression between the sexes. In C. elegans, dosage compensation is achieved by the activity of the dosage compensation complex (DCC).
Emily Petty +2 more
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The dosage-compensation complex in flies and humans.
Genome biology, 2004 A report on the 6th EMBL Transcription Meeting, Heidelberg, Germany, 28 August-1 September 2004.
Bouazoune, Karim +2 more
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The Effect of Hybridization on Dosage Compensation in Member Species of the Anopheles gambiae Species Complex [PDF]
Genome Biology and Evolution, 2018 Abstract Dosage compensation has evolved in concert with Y-chromosome degeneration in many taxa that exhibit heterogametic sex chromosomes. Dosage compensation overcomes the biological challenge of a "half dose" of X chromosome gene transcripts in the heterogametic sex.
Deitz, Kevin C. +2 more
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Condensin-mediated chromosome organization and gene regulation
Frontiers in Genetics, 2015 In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the ...
Alyssa Christine Lau +1 more
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The MSL complex: juggling RNA–protein interactions for dosage compensation and beyond
Current Opinion in Genetics & Development, 2015 The Male Specific Lethal (MSL) complex provides an exquisite example of an epigenetic modulator that is involved in chromosome-wide as well as individual gene regulation in flies and mammals. In this review, we discuss the recent advances in biochemical and structural understanding of the MSL complex modules and how they function in X chromosome ...
Keller, C., Akhtar, A.
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Chromosome-wide gene-specific targeting of theDrosophiladosage compensation complex [PDF]
Genes & Development, 2006 The dosage compensation complex (DCC) ofDrosophila melanogasteris capable of distinguishing the single male X from the other chromosomes in the nucleus. It selectively interacts in a discontinuous pattern with much of the X chromosome. How the DCC identifies and binds the X, including binding to the many genes that require dosage compensation, is ...
Gregor D, Gilfillan +6 more
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Cells, 2020 Chromosome-specific regulatory mechanisms provide a model to understand the coordinated regulation of genes on entire chromosomes or on larger genomic regions. In fruit flies, two chromosome-wide systems have been characterized: The male-specific lethal (
Samaneh Ekhteraei-Tousi +2 more
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Sequence-Specific Targeting of Drosophila roX Genes by the MSL Dosage Compensation Complex [PDF]
Molecular Cell, 2003 MSL complexes bind the single male X chromosome in Drosophila to increase transcription approximately 2-fold. Complexes contain at least five proteins and two noncoding RNAs, roX1 and roX2. The mechanism of X chromosome binding is not known. Here, we identify a 110 bp sequence in roX2 characterized by high-affinity MSL binding, male-specific DNase I ...
Park, Yongkyu +6 more
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Correct dosage of X chromosome transcription is controlled by a nuclear pore component
Cell Reports, 2021 Summary: Dosage compensation in Drosophila melanogaster involves a 2-fold transcriptional upregulation of the male X chromosome, which relies on the X-chromosome-binding males-specific lethal (MSL) complex.
Jennifer R. Aleman +7 more
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Clustered DNA motifs mark X chromosomes for repression by a dosage compensation complex [PDF]
Nature, 2006 Gene expression in metazoans is regulated not only at the level of individual genes but also in a coordinated manner across large chromosomal domains (for example centromeres, telomeres and imprinted gene clusters) and along entire chromosomes (for example X-chromosome dosage compensation).
Patrick, McDonel +3 more
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