Results 61 to 70 of about 663,689 (174)

Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning

Molecular Systems Biology
Aneuploidy, a hallmark of cancer, alters chromosome copy numbers and with that the abundance of hundreds of proteins. Evidence suggests that levels of proteins encoded on affected chromosomes are often buffered toward their abundances observed in ...
Erik Marcel Heller, Karen Barthel, Markus Räschle, Klaske M Schukken, Jason M Sheltzer, Zuzana Storchová   +5 more
doaj   +1 more source

Dosage compensation: X-repress yourself [PDF]

Current Biology, 1997
Dosage compensation in Caenorhabditis elegans involves the sex-specific recruitment to the X chromosome of a protein complex, the nature of which suggests that there are mechanistic links between chromosome segregation and global transcriptional regulation.
Wood, William B., Streit, Adrian, Li, Weiqing   +2 more
openaire   +2 more sources

X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies

BMC Genomics
Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi   +8 more
doaj   +1 more source

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels

Nature Communications
Gene dosage compensation mechanisms are crucial for mammalian development. In mice, recent findings show that cells can sense the number of X chromosomes.
Ryan N. Allsop, Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Suresh Poovanthingal, Wilfred F. J. van IJcken, Jeroen A. A. Demmers, Hegias Mira Bontenbal, Cristina Gontan, Joost Gribnau, Vincent Pasque   +10 more
doaj   +1 more source

Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

Computational and Structural Biotechnology Journal, 2020
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran, Idan Hekselman, Lena Novack, Esti Yeger-Lotem   +3 more
doaj   +1 more source

Dosage compensation rox!

Current Opinion in Cell Biology, 2000
Recent advances in our understanding of dosage compensation in flies have centered on characterizing its sex-specificity, identifying the structural RNAs involved in the process, and determining how dosage compensation is targeted to particular sites on the X chromosome.
A, Franke, B S, Baker
openaire   +2 more sources

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development.

PLoS Genetics
Differentiated sex chromosomes are frequently associated with major transcriptional changes: the evolution of dosage compensation (DC) to equalize gene expression between the sexes and the establishment of meiotic sex chromosome inactivation (MSCI).
Jelisaveta Djordjevic, Patrick Tran Van, William Toubiana, Marjorie Labédan, Zoé Dumas, Jean-Marc Aury, Corinne Cruaud, Benjamin Istace, Karine Labadie, Benjamin Noel, Darren J Parker, Tanja Schwander   +11 more
doaj   +1 more source

Other title: BWC safety violations investigation unit : Summary of ... trends and strategies; Other title: Summary of ... trends and future strategies

, 2011
Annual; Ended with: Fiscal Year 2011."This summary report presents the condition of workers' compensation safety violation investigations in Ohio. The report reviews the BWC special investigations department (SID) safety violations investigation unit ...
Ohio. Bureau of Workers' Compensation. Safety Violations Investigation Unit,
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Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos

BMC Genomics, 2010
Background Considerable progress has been made in our understanding of sex determination and dosage compensation mechanisms in model organisms such as C. elegans, Drosophila and M. musculus.
Mathur Sachin, Zhang Shaobing O, Hattem Gaye, Tassy Olivier, Pourquié Olivier   +4 more
doaj   +1 more source

Other Titles: Biennial Report of the Kansas Office of Workmen's Compensation Commissioner and its successors, 1960-1976 Office of Workmen's Compensation Commissioner (1960) Office of Workmen's Compensation Director (1962) Workmen's Compensation Director (1964-1974) Workmen's Compensation Commission (1976)

, 1960
These biennial reports are summaries of the activities of this agency. They were extracted from a series of Kansas agency reports covering over 100 state agencies and institutions bound together for each biennium, 1959/1960 - 1979/1980.
Kansas. Division of Workers' Compensation.
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