Results 41 to 50 of about 1,171,051 (326)
bioRxiv, 2021 Sex chromosomes have evolved repeatedly across the tree of life. As they are present in different copy numbers in males and females, they are expected to experience different selection pressures than the autosomes, with consequences including a faster ...
D. Parker +4 more
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Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development
Cell Reports, 2019 Summary: Dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a model for how genes are targeted for coordinated regulation.
Leila Elizabeth Rieder +2 more
doaj +1 more source
SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2008 In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome.
Anne Spierer +3 more
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The Plant Cell, 2021 The 45S rRNA genes (rDNA) are among the largest repetitive elements in eukaryotic genomes. rDNA consists of tandem arrays of rRNA genes, many of which are transcriptionally silenced. Silent rDNA repeats may act as ‘back-up’ copies for ribosome biogenesis
Francesca Lopez +12 more
semanticscholar +1 more source
Epigenetics & Chromatin, 2018 Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
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Rapid Evolution of Complete Dosage Compensation in Poecilia
bioRxiv, 2021 Dosage compensation balances gene expression between the sexes in systems with diverged heterogametic sex chromosomes. Theory predicts that dosage compensation should rapidly evolve in parallel with the divergence of sex chromosomes to prevent the ...
David C. H. Metzger +3 more
semanticscholar +1 more source
Dosage Compensation in Females with X-Linked Metabolic Disorders
International Journal of Molecular Sciences, 2021 Through the use of new genomic and metabolomic technologies, our comprehension of the molecular and biochemical etiologies of genetic disorders is rapidly expanding, and so are insights into their varying phenotypes.
Patrycja Juchniewicz +7 more
semanticscholar +1 more source
Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation. [PDF]
PLoS Genetics, 2016 Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression.
Guray Kuzu +14 more
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Nuclear Organization and Dosage Compensation [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Dosage compensation is a strategy to deal with the imbalance of sex chromosomal gene products relative to autosomes and also between the sexes. The mechanisms that ensure dosage compensation for X-chromosome activity have been extensively studied in mammals, worms, and flies.
Jennifer C, Chow, Edith, Heard
openaire +2 more sources
The lncRNAs at X Chromosome Inactivation Center: Not Just a Matter of Sex Dosage Compensation
International Journal of Molecular Sciences, 2022 Non-coding RNAs (ncRNAs) constitute the majority of the transcriptome, as the result of pervasive transcription of the mammalian genome. Different RNA species, such as lncRNAs, miRNAs, circRNA, mRNAs, engage in regulatory networks based on their ...
Chiara Siniscalchi +3 more
semanticscholar +1 more source