Results 41 to 50 of about 663,689 (174)
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
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Translating dosage compensation to trisomy 21 [PDF]
Nature, 2013 Down's syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance across an extra chromosome can be de facto corrected by manipulating a single gene, XIST (the X-inactivation gene).
Jiang, Jun +17 more
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Condensin function in dosage compensation [PDF]
Epigenetics, 2009 Dosage compensation is an essential process that equalizes X-linked gene dosage between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in
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Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]
PLoS Genetics, 2008 X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston +5 more
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Compensation Review Board (CRB) opinions. 2007
, 2007 Updated annually; Began in 2003?; Title from home page last rev. Feb. 6, 2007 (publisher's web site, viewed Mar.
Connecticut. Workers' Compensation Commission. Compensation Review Board.
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X-Chromosome dosage compensation [PDF]
WormBook, 2005 In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes. In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products.
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Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos
Scientific Reports, 2021 Dosage compensation is a mechanism that equalizes sex chromosome gene expression between the sexes. In Drosophila, individuals with two X chromosomes (XX) become female, whereas males have one X chromosome (XY).
Ryoma Ota +4 more
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A sequence motif enriched in regions bound by the
BMC Genomics, 2010 Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood.
Aldecoa Rodrigo +3 more
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Dosage compensation can buffer copy-number variation in wild yeast
eLife, 2015 Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy,
James Hose +5 more
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DOSAGE COMPENSATION: REGULATION OF SEX CHROMOSOME GENE EXPRESSION
Вавиловский журнал генетики и селекции, 2014 Dosage compensation is observed in various taxa of organisms with heteromorphic sex chromosomes. Dosage compensation mechanisms are thought to have arisen to eliminate differences in gene dosage between sexes that appeared in the course of sex chromosome
E. V. Dementyeva
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