Results 161 to 170 of about 432,722 (348)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

New drugs and dosage forms

American Journal of Health-System Pharmacy, 2019
  +9 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Validated Isocratic Reverse Phase-HPLC Method for the Quantitative Estimation of Gemifloxacin in Bulk and Pharmaceutical Dosage Forms

, 2012
Potnuri Naga Raju, G Devala Rao, Prasad Rajendra   +2 more
openalex   +1 more source

APPLICATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF RACECADOTRIL AND OFLOXACIN IN THEIR PHARMACEUTICAL DOSAGE FORM [PDF]

, 2019
Mohamed R. Kamel
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

EXCIPIENTS IN ORAL SUSPENSIONS

Разработка и регистрация лекарственных средств, 2019
The article describes the approaches to classification and separation of groups of excipients in oral suspensions of both domestic and foreign authors. A number of existing classifications of excipients for oral suspensions are presented. The analysis of
V. V. Vernikovsky, E. V. Tretyakova
doaj  

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Simultaneous equation method for the estimation of Lamivudine, Nevirapine and Zidovudine in Bulk and tablet dosage forms

, 2014
Ramesh Jayaprakash, Senthilkumar Natesan, Vijay Amirtharaj Ramasamy, Rajasekhar Kommi, Kiran R Gandhi   +4 more
openalex   +1 more source

DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY FOR AZILSARTAN KAMEDOXOMIL IN SOLID DOSAGE FORMS. [PDF]

, 2016
MohamedA. Kassem, MagdyI. Mohamed, A El Mubarak Mohamed   +2 more
openalex   +1 more source