Results 31 to 40 of about 432,722 (348)

The research on creation the dosage form based on 3-(4-nitrophenyl)-5-(nonylsulfonyl)-1,2,4-triazol-4-amine

Zaporožskij Medicinskij Žurnal, 2014
The search of new biologically active substances, which can be potential drugs with low toxicity and high levels of biological effects, is one of the major aims of modern medicine and pharmacy. Chemical modification of heterocyclic molecules, such as 1,2,
M. A. Shcherbak, A. G. Kaplaushenko, N. N. Maletskiy, Ye. A. Sharaya   +3 more
doaj   +1 more source

Biowaiver Monographs for Immediate‐Release Solid Oral Dosage Forms: Codeine Phosphate [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106898/1/jps23977 ...
Abrahamsson, Bertil, Amidon, Gordon L., Cristofoletti, Rodrigo, Dahan, Arik, Dressman, Jennifer B., Groot, D. W., Kopp, Sabine, Langguth, Peter, Polli, James E., Shah, Vinod P., Wolk, Omri, Zur, Moran   +11 more
core   +1 more source

Development of Orally Disintegrating Tablets of Standardized Rhodiola rosea Extract

Pharmaceuticals
Background/Objectives: Rhodiola rosea L. (Crassulaceae), a perennial adaptogenic herb native to Northern Europe, Asia, and North America, is renowned for its therapeutic properties attributed to phenolic compounds including flavonoids, phenylethanoids ...
Oxana Brante, Rihards Talivaldis Bagons, Santa Niedra, Austris Mazurs, Baiba Mauriņa, Jurga Bernatoniene, Konstantins Logviss   +6 more
doaj   +1 more source

Progress in the development of mRNA vaccine and its delivery systems for anti-tumor immunotherapy [PDF]

Zhongguo aizheng zazhi
Due to the drawbacks of low specificity and high risk of side effects of traditional anti-tumor treatments in clinical practice, novel anti-tumor immunotherapy has received attention and has been gradually applied.
XIN Meiyi, LIN Yuhong, ZHAO Kai
doaj   +1 more source

Antibacterial Activity of Novel Agent N-2-Hydroxypropyl Trimethyl Ammonium Chloride Chitosan against Streptococcus mutans

Molecules
Dental caries (DC) is one of the most common oral diseases and is mainly caused by Streptococcus mutans (S. mutans). The use of antibiotics against S. mutans usually has side effects, including developing resistance.
Yuan Gao, Xiaochen Gong, Qicheng Ruan, Chunjing Zhang, Kai Zhao   +4 more
doaj   +1 more source

Determination of the Antiprotozoal and Antibacterial Drug Metronidazole in Blood and Dosage Forms Using a Simple Spectrophotometric Method

Pakistan Journal of Analytical & Environmental Chemistry, 2022
A new, precise, and sensitive method for the determination of Metronidazole has been created. Metronidazole has been determined in both blood and dosage forms.
Ann H. Mahmood , Hana Sh. Mahmood
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Pilot trial of fk 506 in the management of steroid-resistant nephrotic syndrome [PDF]

, 1993
Seven patients with steroid-resistant nephrotic syndrome were treated with FK 506 monotherapy. Four patients were children with focal sclerosing glomerulonephritis (FSGS).
Ellis, D, Igdal, H, McCalley, J, Shapiro, R, Shapiro, R, Starzl, TE, Starzl, TE, Starzl, TE, Tzakis, A, Tzakis, A   +9 more
core   +1 more source

ANTITUBERCULOSIS DRUG DOSAGE FORMS: RANGE, KEY BENEFITS AND PROSPECTS OF TECHNOLOGICAL IMPROVEMENT

Фармация и фармакология (Пятигорск), 2016
Interest to research in the development of new formulations of antituberculosis drugs due to the high incidence of tuberculosis in the Republic of Kazakhstan and the Russian Federation nowadays, including with acquired drug resistance. The reason for the 
M. E. Kim, K. B. Murzagulova, E. F. Stepanova   +2 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source