Results 61 to 70 of about 439,656 (359)

Engineered probiotics for inflammatory bowel disease therapy: mechanisms, delivery strategies, and precision medicine

Frontiers in Microbiology
Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), is a prevalent chronic gastrointestinal disorder. Conventional therapies are often limited by adverse effects and suboptimal long-term efficacy.
Xiaohua Wang, Yindi Cheng, Jiahui Huang, Feixuan Xu, Jian Jiang, Nonthaneth Nalinratana, Litong Jin, Ying Xue   +7 more
doaj   +1 more source

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]

, 2017
Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh, Chen, Yanbin, Chin, Adave, Hirabayashi, Yoko, Hirata, Tsuyoshi, Nagarajan, Narayani, Naito, Daichi, Oka, Shin-Ichi, Sadoshima, Junichi, Saito, Toshiro, Schesing, Kevin, Sciarretta, Sebastiano, Shao, Dan, Suzuki, Wataru, Yaginuma, Hiroaki, Yodoi, Junji, Zhai, Peiyong   +16 more
core   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Development of a Formulation and In Vitro Evaluation of a Pulmonary Drug Delivery System for a Novel Janus Kinase (JAK) Inhibitor, CPL409116

Pharmaceutics
The pursuit of targeted therapies for cytokine-dependent diseases has led to the discovery of Janus kinase (JAK) inhibitors, a promising class of drugs.
Aleksandra Rzewińska, Jakub Szlęk, Damian Dąbrowski, Ewelina Juszczyk, Katarzyna Mróz, Heikki Räikkönen, Mia Siven, Maciej Wieczorek, Przemysław Dorożyński   +8 more
doaj   +1 more source

Nifuroxazide Pharmaceutical Preparations in the Russian Federation. Publication One: Nomenclature, Chemical and Pharmaceutical Characteristics of the Preparations’ Composition

Антибиотики и Химиотерапия, 2021
One of the most used antimicrobial nitrofurans in Russian medical practice is nifuroxazide, which is distinguished by high therapeutic efficacy, drug safety, as well as economic availability in the treatment of acute bacterial diarrhea without ...
V. I. Kocherovets, S. G. Mardanly
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Triggerable tough hydrogels for gastric resident dosage forms [PDF]

, 2017
Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ...
Booth, Lucas, Cleveland, Cody, Kirtane, Ameya, Langer, Robert S, Lee, Young-Ah, Lin, Jiaqi, Liu, Jinyao, Mazdiyasni, Hormoz, Pang, Yan, Rogner, Jaimie L, Saxton, Sarah, Traverso, Carlo Giovanni, von Erlach, Thomas C, Yin, Xiaolei, Zhang, Shiyi   +14 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Liquid dosage forms with antibacterial activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The development and implementation of effective liquid medicines with antiseptic action on the basis of new substances and their complex combinations into medical practice is an important task of modern pharmaceutical and medical science.
O. I. Mykhalyk
doaj   +1 more source

Study of the Acidification of Sherry Musts With Gypsum and Tartaric Acid [PDF]

, 1993
Must acidification is a necessary operation in hot regions due to the low natural acid content of the grapes grown there. Tartaric acid is what is most usually used for this purpose.
Diez Martín, Juan, Grandal Delgado, María del Mar, Gómez Benítez, Juan   +2 more
core   +1 more source