Results 31 to 40 of about 1,337,629 (257)

PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response. [PDF]

, 2016
PurposeThe purpose of our study is to determine if there is a relationship between dose deposition measured by PET/MRI and individual lesion response to yttrium-90 ((90)Y) microsphere radioembolization.Materials and methods26 patients undergoing lobar ...
Fowler, Kathryn J, Laforest, Richard, Maughan, Nichole M, Olsen, Jeffrey, Parikh, Parag J, Saad, Nael E, Sharma, Akash, Speirs, Christina K   +7 more
core   +2 more sources

Model Selection versus Model Averaging in Dose Finding Studies [PDF]

, 2015
Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn, Bretz, Frank, Dette, Holger, Schorning, Kirsten   +3 more
core   +2 more sources

Preclinical Evaluation of Botulinum Toxin Type E (TrenibotulinumtoxinE) Using the Mouse Digit Abduction Score (DAS) Assay

Toxins
TrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson, David Canty, Annemarie Southern, Kevin Whelan, Amy D. Brideau-Andersen, Ron S. Broide   +5 more
doaj   +1 more source

The H-ARS Dose Response Relationship (DRR): Validation and Variables [PDF]

, 2015
Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality.
Chua, Hui Lin, Feng, Hailin, Fisher, Alexa, Jackson, William, MacVittie, Thomas J., Orschell, Christie M., Plett, P. Artur, Sampson, Carol H., Sellamuthu, Rajendran, Vemula, Sasidhar, Wu, Tong   +10 more
core   +1 more source

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag, Mikić Dragan, Arsić-Komljenović Gordana, Stanković Nebojša, Ristanović Elizabeta, Sjeničić Goran, Janićijević-Hudomal Snežana   +6 more
doaj   +1 more source

Analysis of the Dose-Response Effects of Physical Activity on Cardiocerebrovascular and All-Cause Mortality in Hypertension

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeisure-time moderate-to-vigorous physical activity (MV-PA) has been consistently regarded as a protective factor to prevent and treat hypertension.
Jun-Peng Xu, Jun-Peng Xu, Rui-Xiang Zeng, Rui-Xiang Zeng, Hai-Ning Lu, Yu-Zhuo Zhang, Yu-Zhuo Zhang, Xiao-Yi Mai, Xiao-Yi Mai, Shuai Mao, Shuai Mao, Min-Zhou Zhang, Min-Zhou Zhang   +12 more
doaj   +1 more source

Influence of Multiple Traumatic Event Types on Mental Health Outcomes: Does Count Matter? [PDF]

, 2018
The experience of potentially traumatizing events (PTEs) may be associated with conflicting outcomes: individuals may experience greater psychological distress (dose-response theory), or individuals may become more resilient against repeated PTEs (stress-
Brown, Lily A, Contractor, Ateka A, Dranger, Paula, Frankfurt, Sheila B, Gerber, Monica M, Oudshoorn, Kelsey   +5 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis

BMC Nephrology
Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. Objectives To elucidate the dose-response relationship between lipids and all-cause mortality in the dialysis
Ye Yao, Jing Xiong, Mi-Yuan Wang
doaj   +1 more source