Results 71 to 80 of about 978,397 (252)

Optimal designs for dose-response models with restricted design spaces [PDF]

In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for ...
Zhu, Wei, Dette, Holger, Biedermann, Stefanie   +2 more
core  

Dose-response relationship and low dose extrapolatioin in chemical carcinogenesis [PDF]

, 1990
Data supporting various dose-response relationships in chemical carcinogenesis are summarized. General principles are derived to explain the relationships between exposure dose, DNA adduct level, induction of genetic changes, and tumor incidence.
Lutz, Werner K
core   +1 more source

CRP–triglyceride–glucose index (CTGI) as a predictor of preeclampsia: a population-based study of risk stratification

Lipids in Health and Disease
Background preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality worldwide. While metabolic and inflammatory factors are increasingly recognized in its pathogenesis, the clinical utility of composite biomarkers ...
Yuting Liang, Yanqiu Zhang, Yujing Li, Jun Cao, Bin Feng, Jieyu Jin, Sheng Zhang, Qingqin Tang, Longwei Qiao, Zhixing Jin   +9 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Practical considerations for optimal designs in clinical dose finding studies [PDF]

Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger, Pinheiro, José, Bretz, Frank   +2 more
core  

Dose response relationship of headache to topiramate dose.

, 2015
Dose response relationship of headache to topiramate dose.
Jeffrey L. Jackson (147204), Rafael Santana-Davila (769651), Andrew Gradall (769654), Elizabeth Cogbill (769650), Jessica Kuester (769655), Christina Eldredge (769652), Neha Sehgal (326548), William Collier (769653)   +7 more
core   +1 more source

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy

Heliyon
Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng, Shuang Yu, Liang-Yuan Lu   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship

, 2014
Background and objectiveWalking and cycling have shown beneficial effects on population risk of all-cause mortality (ACM). This paper aims to review the evidence and quantify these effects, adjusted for other physical activity (PA).Data sourcesWe ...
Thomas Götschi, Foster, C, Scarborough, Peter, Kahlmeier, Sonja, Nia Roberts, Goetschi, T, Götschi, Thomas, Paul Kelly, Scarborough, P, Orsini, Nicola, Richards, Justin, Kahlmeier, S, Richards, J, Charlie Foster, Götschi, T, Foster, Charlie, Orsini, N,, Sonja Kahlmeier, Nicola Orsini, Peter Scarborough, Roberts, N, Foster, Charles, Orsini, N, Kelly, Paul, Roberts, Nia, Justin Richards, Kelly, P   +26 more
core   +1 more source

Comparison of the potency-ratio of ciprofol and propofol on sedative effects in painless hysteroscopy: a randomized double-blind dose-response study

BMC Anesthesiology
Purpose Ciprofol has been investigated as a potential alternative to propofol for anesthesia because of its tendency to depress the respiratory and circulatory systems to a lesser extent and its association with less pain during injection.
Yu Zhang, Xiaoping Chen, Lin Jin, Xinzhong Chen, Xiaowei Qian   +4 more
doaj   +1 more source