Results 61 to 70 of about 11,692,584 (245)
Code for Bayesian inference of dose-response curve parameters
, 2016 <p>This is an archived version of the initial release of dose-response-fitting to co-incide with a Wellcome Open Research article.</p> <p>The latest version can be found at: <a href="https://github.com/mirams/dose-response-fitting ...
Bardenet, Remi +7 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Application of the Linear-Quadratic model to targeted radionuclide therapy [PDF]
, 2011 PhDThe principal aim of this work was to test the hypothesis that the Linear-Quadratic (LQ) model of cell survival, developed for external beam radiotherapy (EBRT), could be extended to targeted radionuclide therapy (TRT) in order to predict dose ...
Murray, Iain
core +4 more sources
Frontiers in PhysiologyBackgroundTo compare the effects of various exercise modalities on intelligence and determine the optimal exercise dose for children and adolescents.MethodsA systematic review and Bayesian network meta-analysis following PRISMA guidelines was conducted ...
Yan Wang +9 more
doaj +1 more source
Dose-response relationship between tooth loss and risk of cardiovascular disease.
, 2018 Dose-response relationship between tooth loss and risk of cardiovascular disease.
Mi Zhang (42795) +8 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Dose-response relationship between tobacco smoking and the risk of composite TB treatment outcomes.
, 2019 Dose-response relationship between tobacco smoking and the risk of composite TB treatment outcomes.
Nikhil Gupte (189999) +22 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2009 A re-interpretation of the ‘Dose-Response’ curve is given that accommodates homeostasis. The outcome, or overall effect, of toxicity is the consequence of toxicity that is moderated by homeodynamic responses.
Stebbing, ARD, A.R.D. Stebbing
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source