Results 81 to 90 of about 1,326,462 (264)

A U-shaped dose–response of carbohydrate–protein supplementation on rowing performance

Frontiers in Nutrition
Background and aimCo-ingestion of carbohydrate and protein supplement (CHO–PRO) is a common strategy to enhance endurance performance. However, the optimal dose–response relationship has not been established, which limits evidence-based nutritional ...
Xiangyu Wang, Xiangyu Wang, Hao Wu
doaj   +1 more source

Practical considerations for optimal designs in clinical dose finding studies [PDF]

Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Bretz, Frank, Dette, Holger, Pinheiro, José   +2 more
core  

Test Of Homogeneity For Umbrella Alternatives In Dose-Response Relationship For Poisson Variables [PDF]

, 2003
This article concerns the testing and estimation of a dose-response effect in medical studies. We study the statistical test of homogeneity against umbrella alternatives in a sequence of Poisson distributions associated with an ordered dose variable.
Ji, Ming, Xiong, Chengjie, Yan, Yan
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

CRP–triglyceride–glucose index (CTGI) as a predictor of preeclampsia: a population-based study of risk stratification

Lipids in Health and Disease
Background preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality worldwide. While metabolic and inflammatory factors are increasingly recognized in its pathogenesis, the clinical utility of composite biomarkers ...
Yuting Liang, Yanqiu Zhang, Yujing Li, Jun Cao, Bin Feng, Jieyu Jin, Sheng Zhang, Qingqin Tang, Longwei Qiao, Zhixing Jin   +9 more
doaj   +1 more source

Effects of the Shape of the Radiation Dose-Response Curve on Public Acceptance of Radiation and Nuclear Energy [PDF]

, 2002
[Excerpt] “The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase.
Fentiman, Audeen W.
core   +1 more source

An investigation of thresholds in air pollution-mortality effects [PDF]

, 2004
In this paper we introduce and implement new techniques to investigate threshold effects in air pollution-mortality relationships. Our key interest is in measuring the dose-response relationship above and below a given threshold level where we allow for ...
Clyde, Daniels, Delfino, Dockery, Dominici, Draper, Fairly, Fernandez, Fernandez, Gary Koop, Hodges, Hoeting, Hurley, Koop, Koop, Lim, Lise Tole, Madigan, Meng, Ordieres, Ostro, Pope, Raftery, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Smith, Xu   +36 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy

Heliyon
Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng, Shuang Yu, Liang-Yuan Lu   +4 more
doaj   +1 more source

Dose-response relationship between sports activity and musculoskeletal pain in adolescents. [PDF]

, 2016
Physical activity has multiple health benefits but may also increase the risk of developing musculoskeletal pain (MSP). However, the relationship between physical activity and MSP has not been well characterized.
Abe, Takafumi, Imamura, Fumiaki, Kadowaki, Masaru, Kamada, Masamitsu, Kitayuguchi, Jun, Lee, I-Min, Matsui, Yuzuru, Miyachi, Motohiko, Sawada, Susumu S, Uchio, Yuji   +9 more
core   +2 more sources