Results 81 to 90 of about 8,423,709 (341)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation

Scientific Reports
Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin.
Min Liao, Xiao-Ru Wu, Jia-Ning Hu, Xing-Zhou Lin, Tang‑yuan‑meng Zhao, Hu Sun   +5 more
doaj   +1 more source

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]

, 2017
BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials.
AE Raftery, EH Choy, EJ Calabrese, F Behrens, Feng Liu, J Arrowsmith, J Fransen, J Heydari, K Almstrup, M Hay, MK Smith, N Thomas, P Brain, SC Owen, Stephen J. Walters, Steven A. Julious, W Stohl, Z Skrivanek   +17 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Association between exposure to noise and risk of hypertension: A meta-analysis of observational epidemiological studies [PDF]

, 2017
Background and Objective: An increasing amount of original studies suggested that exposure to noise could be associated with the risk of hypertension, but the results remain inconsistent and inconclusive.
Cao, Shiyi, Fu, Wenning, Gan, Yong, Liu, Qiaoyan, Lu, Zuxun, Song, Fujian, Wang, Chao, Wang, Zhihong, Yan, Shijiao, Zou, Li   +9 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations [PDF]

, 1991
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence.
A.M. Kellerer, D. Chmelevsky, Douglas B.G., Douglas B.G., Efron B, Efron B, Guttenberger R., Han A.K, Henkelman R.M., J. Kummermehr, Kellerer A.M., Kummermehr J., Lam G.K.Y., Maciejewski B., R. Guttenberger, Taylor J.M.G., Thames H.D, Tucker S.L, Vegesna V., Williams M.V.   +19 more
core   +1 more source

Is There a Dose–Response Relationship of Cement Volume With Cement Leakage and Pain Relief After Vertebroplasty?

Dose-Response, 2016
The aim of this study was to determine if there were dose–response relationships of cement volume with cement leakage and pain relief after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs).
Zhiyi Fu, Xiaopeng Hu, Yu-jie Wu, Zihui Zhou   +3 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effects of the Shape of the Radiation Dose-Response Curve on Public Acceptance of Radiation and Nuclear Energy [PDF]

, 2002
[Excerpt] “The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase.
Fentiman, Audeen W.
core   +1 more source