Results 111 to 120 of about 7,945,859 (267)
Linear No-Threshold Model vs. Radiation Hormesis
Dose-Response, 2013 The atomic bomb survivor cancer mortality data have been used in the past to justify the use of the linear no-threshold (LNT) model for estimating the carcinogenic effects of low dose radiation.
Mohan Doss
doaj +1 more source
, 2017 Dose-response curves for grifolic acid (□; GPR120 agonist), Arachidonic acid (▲), GPR120 agonist III (■), GPR40 agonist (PPMAPP; ○) and GPR40 agonist II (●)-induced release of intracellular Ca2+ in round spermatids vs. their concentrations.
Claudia L. Treviño (262420) +7 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
, 2005 Non-linear dose response relationships pose statistical challenges for their discovery. Even when an initial linear approximation is followed by other approaches, the results may be misleading and, possibly, preclude altogether the discovery of the ...
Carol Bigelow, Susanne May
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Dose-Response, 2010 Tumor angiogenesis, the growth of new blood vessels into tumors, facilitates tumor growth and thus represents an attractive therapeutic target. Numerous experimental angiogenesis inhibitors have been characterised and subsequently trialled in patients ...
Andrew R. Reynolds
doaj +1 more source
Geometric construction of optimal designs for dose-responsemodels with two parameters [PDF]
In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a ...
Zhu, Wei +2 more
core
, 2013 Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis.
Brian O. Piotrowski +15 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Dose-Response, 2019 Sodium meta-arsenite (NaAsO 2 ) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug.
Johan Lundqvist +2 more
doaj +1 more source