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Relationship between absorbed dose and SUV derived from SPECT/CT imaging and dose-response in patients with neuroendocrine tumors treated with [¹⁷⁷Lu]Lu-DOTA-TATE. [PDF]

EJNMMI Res
Liu F, Yang H, Zhang J, Li J, Qiao Y, Chen J, Song S.   +6 more
europepmc   +1 more source

Complex versus simple <i>N</i>-nitrosamines: Comprehensive genotoxicity and in silico carcinogenicity assessment toward future testing paradigms. [PDF]

Sci Adv
Sun X, Schuler M, Zhang S, Kostal J, Cheung JR, Kenyon M, Watt E, Dobo K.   +7 more
europepmc   +1 more source

Applications of Pharmacometrics in Antibody-Drug Conjugate Development. [PDF]

Pharmaceutics
Cheng X, Ji S, Lee Y, Dong H.
europepmc   +1 more source

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Treatment Intensity and Reduction in Drug Use for Cocaine-Dependent Methadone Patients: A Dose-Response Relationship

Journal of Psychoactive Drugs, 1995
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Andrew Rosenblum, Stephen Magura, Michael Palij   +2 more
exaly   +3 more sources

An Alternate Method for Estimating the Dose-Response Relationships of Neuromuscular Blocking Drugs

Anesthesia & Analgesia, 2000
Slopes of the dose-response relationships for all available neuromuscular blocking drugs appear to be essentially parallel and to approximate a log-dose/logit value of 4.75. We tested the possibility of estimating both 50% effective dose (ED(50)) and 95% effective dose (ED(95)) values from a single dose-response data point when that slope is postulated.
A F, Kopman, M M, Klewicka, G G, Neuman
openaire   +2 more sources

The multiple propensity score for analysis of dose–response relationships in drug safety studies

Pharmacoepidemiology and Drug Safety, 2001
AbstractIn order to detect adverse drug reactions, large observational drug safety studies are necessary as randomized clinical trials rarely have enough power. However, in order to obtain reliable results the issue of confounding, especially confounding by indication, should be addressed.
Wang, Jixian, Donnan, Peter T., Steinke, Douglas, MacDonald, Thomas M.   +3 more
openaire   +3 more sources

Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
openaire   +2 more sources