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Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]
, 2015 Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...H. K. Salem, Langie, A. S. Sabine, Koppen, G., Colacci, Anna Maria, Yunus Luqmani, James E. Klaunig, Guarnieri, Tiziana, R. Andrade Vieira, Jan Vondráček, Rabindra Roy, Hsu, C-W, Laconi, E., I. Koturbash, A. Ward, S. Luanpitpong, Patricia A. Thompson, Otsuki T, Lyerly, H.K., Naus, C., Vento R, Hsu, H. Y., Romano MF, Whitfield, Jonathan R, Silvana Papagerakis, Salzberg, A. C., Bisson, H. William, Kuemmerle, Nancy B., Klaunig JE, Amaya Azqueta, Sudjit Luanpitpong, Ahmed, Nuzhat, Collins, Andrew R., Vermeulen, Louis, Van Schooten FJ, Vaccari, Monica, Dent, P., Z. Chen, J. Roman, Felsher, Dean W., Whitfield, J., Hultman, Tove, Martin, F. L., Christopher, JA, Carnero A, Ghosh PM, R. Vento, Otsuki, T, Sabbisetti V, Narayanan, K. B., Ponce-Cusi, Richard, Amedei, Amedeo, Kannan Badri Narayanan, Engström, Wilhelm, Whitfield, JR, Harris, Shelley A., Leung, P. S., Vondráček, J, Di Fiore, R., Thompson, P., Ochieng, J, Matilde E. Lleonart, Koppen, G, Kleinstreuer, Nicole, Bisson, William H., Nahta R, Riccardo Di Fiore, Fernando Martinez-Leal, Juan, Forte S, Singh, Neetu, J. Ochieng, Sabbisetti, Venkata, Marignani PA, Thompson, Patricia, Curran, Colleen S, Carlin, J. Danielle, Hultman, T., Y. Luqmani, Wade, M., Kondoh, H, Rathmell WK, Ranjeet K. Sinha, Ab Hamid, H., Lee, TJ, Kim Moorwood, Ward, Andrew, Christopher, A. Joseph, Marignani, Paola A, Anna C. Salzberg, Jian, L., Gonzalez, Michael J, Lyerly, H Kim, Ghosh, Paramita M, Goodson III, William H, A. Lopez de Cerain Salsamendi, Chen Z, F. Marongiu, Salzberg AC, Decker WK, Manjili, Masoud H, Vadgama, P., Dong C, Chen T, Anna Maria Colacci, Salem, Hosni K, Olsen, Ann-Karin, G. Wagemaker, Sanderson T, E. Ratovitski, Odero-Marah, V, Gonzalez, L, Z. Hu, Raju, J., Odero Mara, Valerie, Eun-Yi Moon, Collins, A. R., L. Leyns, Krishnan, Harini, Salzberg, A.C., Ogunkua, Olugbemiga, S. Forte, Wise Sr., John Pierce, Abd Hamid, R, Narayanan, Kannan Badri, Laconi, E, Bisson, William H, J. P. Wise, Hyun, Ho Park, Soucek, L., Rojas, Emilio, Rojanasakul, Yon, Sandra Ryeom, Kondoh H, Rojanasakul Y, Harini Krishnan, Guarnieri, T., Scovassi, a Ivana, Nangami, Gladys N., Colacci, Annamaria, Koturbash, I., Karamouzis, Michalis V, Darbre, P., S. Eriksson, McCawley, Lisa J., F. Al Mulla, Lyerly HK, Ostrosky Wegman P, Goldberg GS, A. R. Collins, Ali, Abdul Manaf, Jonathan R. Whitfield, Emanuela Corsini, Nancy B. Kuemmerle, Lleonart, Matilde E, Cheng, Q. S., Langie, Sabine A.S., Lee, T., Nicole Kleinstreuer, Ab Hamid, Hasiah, Sofia Pavanello, Yedjou, C, Jian, Le, Sinha, K. Ranjeet, Yedjou C, Massfelder T, F. L. Martin, Pavanello, S, Valverde, M., Micheline Kirsch-Volders, Valérian Dormoy, H. Yasaei, Collins, A., Massfelder, T, Laird, Dale W., A. Manaf Ali, Ghosh, M. Paramita, H. Sone, Salzberg, C. Anna, Goldberg, G., Hamid, H. A., Clement Yedjou, Carlin, DJ, Ogunkua O, Christian C. Naus, Sinha, Ranjeet K., Scovassi AI, Odero-Marah, Valerie, Nangia Makker, P., Van Schooten, F., Yedjou, C., Harris SA, Eltom, S., Collins, AR, van Larebeke, N, Gonzalez, Michael J., Weisz, J, Singh, N, Memeo, Lorenzo, Barclay, BJ, Ryan, Elizabeth P., Krishnakumar, PK, Park, Hyun Ho, A. I. Scovassi, Elizabeth P. Ryan, Azqueta, A, Salem, H.K., Van Schooten, FJ, Hu, Z, Salem HK, Calaf, Gloria M, Andrew Ward, Leyns L, Eltom, Sakina E., Park, H. H., Carpenter, DO, Krishnakumar, P., C. Yedjou, Wise, S. S., Carpenter DO, Ratovitski E, Carpenter, O. David, Wolf, T. Gregory, Azqueta, A., Forte, Stefano, Prudhomme, K., Dent P, Blanco Aparicio, C., L. Li, Harris, A. Shelley, Sr, WJP, Chapellier, M., Hamid, A. Roslida, Barclay, Barry J., Carlin, D., M. Vaccari, Po Sing Leung, Po, Sing Leung, Williams, P. Graeme, Woodrick, Jordan, Y. Rojanasakul, Karamouzis, V. Michalis, Berg, A., D. C. Koch, Ann-Karin Olsen, Gulliver L, L. Jian, Prudhomme, K. R., Prudhomme, KR, Ghosh, Paramita M., Dormoy, V, Ryan, E.P., G. Williams, Miousse, I. R., Krishnakumar, P. K, Roy, D., Mehta, R., Cohen Solal, Karine A, Hiroshi Kondoh, Charles, A.K., Wolf, GT, Kirsch Volders, M., Kuemmerle, Nancy B, Romano, Simona, Takemi Otsuki, Miousse, IR, Ochieng, J., Hyun Ho Park, Heneberg, P., Luoping Zhang, Zhang, Luoping, Berg A, Al Mulla F, Goldberg, Gary S, Luqmani, Yunus, Mahara Valverde, Tao Chen, Leandro S. D’Abronzo, Lasfar, A., Castellino RC, Van Schooten, Frederik J., M. Xia, de Cerain Salsamendi, A. L., Karamouzis, Michalis V., Nangami, G., J. E. Klaunig, Sabbisetti, V., Charles, A. K., Ward A, Leung, Po Sing, Corsini, Emanuela, Josiah Ochieng, Martin, Francis L., Christopher, J., C. S. Curran, Francis L. Martin, Barclay, B., Al Temaimi R, Sing Leung P, N. B. Kuemmerle, A. C. Salzberg, Yon Rojanasakul, Miousse, I., Nangia-Makker, P, P. Vadgama, Emilio Rojas, Casey, SC, Raju, Jayadev, Gonzalez, M. J., Casey, S., Carlin, D.J., Ochieng, Josiah, Bay, N. Sarah, Manaf Ali A, Wise JP Sr, Goldberg, GS, J. Sun, M. A. Williams, Zhou, P. Binhua, Blanco-Aparicio, Carmen, Mondello C, S. S. Wise, Rita Nahta, Dong, Chenfang, Nangami, Gladys N, Krishnakumar, P K, A. K. Charles, Langie, S. A. S., Wolf, G., Yasaei, H., R. Ponce Cusi, Ward, A., Ostrosky Wegman, Patricia, Gonzalez, Laetitia, Louis Vermeulen, Felsher, D.W., Hsu, Chia-Wen, Prudhomme, Kalan R., Wolf, Gregory T., Brown, D., Lin Li, Guarnieri T, Romano, MF, Gonzalez L, Chenfang Dong, Marongiu F, Palorini R, Andrade-Vieira, R, Romano, M., Ezio Laconi, Koch, D.C., Nangia Makker P, Moorwood, Kim, Marignani, P., Brunborg, G, P.K. Krishnakumar, Vento, R, Dornetshuber-Fleiss, R, Corsini, E., Hamid, HA, Laird, D. W., Marignani, PA, Rojas E, O. Ogunkua, Amedeo Amedei, Martinez-Leal, Juan Fernando, M. F. Romano, III, GWH, Lowe, Leroy, R. Palorini, Rojas, E, Hamid, H., Laconi E, S. A. Harris, Krishnakumar, P. K., Lin, L-T, Andrade Vieira, Rafaela, Christopher, Joseph A., Yedjou, Clement, Andrew R. Collins, Nuzhat Ahmed, Brown, G. Dustin, W. K. Decker, Lin LT, Prudhomme, R. Kalan, Heneberg P, N. Singh, Memeo L, Hosni K. Salem, Lopez de Cerain Salsamendi, A, Liang-Tzung Lin, Ryan, Elizabeth P, Andrade Vieira R, N. van Larebeke, Roy D, Roy R, Hsue, Yin Hsu, Hideko Sone, Cheng, Qiang, Moorwood, K., Odero Marah, V., Rathmell, W Kimryn, S. Papagerakis, Lopez de Cerain Salsamendi, A., Lowe, L., Ahmed, N, Luanpitpong, S, Salsamendi, Adela Lopez de Cerain, R. B. Robey, Sanderson, T, Chiaradonna F, Bay SN, Binhua P. Zhou, de Cerain Salsamendi, Adela Lopez, Cheng, Qiang (Shawn), Mondello, C., L. Gonzalez, Christopher, J. A., Eltom SE, Goldberg, G.S., Ahmed Lasfar, Kimryn Rathmell, W., Goldberg, G. S., Williams, G, Lasfar, A, Barclay, J. Barry, Sinha, RK, Langie, SA, Mehta R, Hsu, H., Salzberg, Anna C., Memeo, L, Casey, C. Stephanie, I. R. Miousse, R. Di Fiore, Darbre, Philippa, Decker, K. William, Van Schooten, F. J., Xia M, Wade, M., et al., Eriksson, Staffan, Sinha, R., Carpenter, D.O., Blanco Aparicio, Carmen, Naus, C.C., Leyns, Luc, Brooks, SA, Palorini, R, Manjili, Masoud H., Hasiah Ab Hamid, Monica Vaccari, Hsu, HY, Cohen-Solal, Karine A, Li L, Krishnan, H., R. K. Sinha, Cohen Solal KA, Robey, R.Brooks, Yasaei, H, Klaunig, J.E., Ryan EP, Langie, S., Al Mulla, Fahd, Williams, Marc A, Baglole, Carolyn J., A. Colacci, Brooks, S., Prudhomme KR, K. Moorwood, Kravchenko, Julia, Collins, A.R., Blanco-Aparicio, C., Amelia K. Charles, Li, L, Odero Marah V, Scovassi, A.Ivana, Fabio Marongiu, F. Chiaradonna, T. Lee, H. Ab Hamid, Cruickshanks, Nichola, Hu Z., Hsu CW, Castellino, R. C., Pavanello, S., Thompson, Patricia A., Romano, S., W. H. Goodson, J. R. Whitfield, Zhou, BP, Barclay, B.J., F. Darroudi, Mccawley, L. J., G. T. Wolf, Carnero, Amancio, Sinha, R. K., Larebeke, Nik van, Williams, G., Decker, W., Langie, Sabine A. S, Carlin, D. J., Vondráček J, Bisson WH, Ali, A. M., Zhou, B., Decker, WK, L. Lin, Dale W. Laird, Wise, John Pierce, Sr., Ratovitski, E., B. J. Barclay, Li, Lin, Papagerakis, S., P. M. Ghosh, H. Hsu, Lleonart, M, A. Azqueta, W. Engström, Ward, A, Zhang L, Koch, D. C., Marion Chapellier, L. Lowe, Hsu, CW, Joseph A. Christopher, Julia Kravchenko, Brooks, S. A., Kravchenko J, Roman, J, Jesse Roman, Khatami, M., Laird, Dale W, III, Nangami, G, Pavanello, Sofia, Nangami, N. Gladys, L. J. Mccawley, Calaf GM, Martin FL, L. Vermeulen, Shelley A. Harris, Ostrosky Wegman, P., S. Pavanello, Zhou, B.P., Williams, M. A., Eltom, S, Leroy Lowe, III, William H. Goodson, Roy, Debasish, Ryeom, Sandra, Thompson PA, Koppen G, Curran, S. Colleen, Hsu, H-Y, Colacci, A, Vaccari, M., R.Brooks Robey, Rathmell, W.Kimryn, P. Nangia Makker, P. Ostrosky Wegman, Yasaei, Hemad, Koppen, Gudrun, Lasfar, Ahmed, M. J. Gonzalez, Ahmed, N., Daniel C. Koch, Charles, K. Amelia, Ab Hamid H, Narayanan, K., Klaunig, James E., Vadgama, P, Marc A. Williams, Hsu, C.W., Martinez-Leal, J.F., Harris, Shelley A, Chiara Mondello, Harris, S. A., Narayanan, KB, P. Dent, Brown, D. G., Cohen-Solal, A. Karine, Li, L., Laird, DW, Wise, J.P., Sr., Chen, Z., Kuemmerle, B. Nancy, Langie, Sabine A. S., H. H. Park, Eriksson, S., de Cerain Salsamendi, A., Carpenter, David O., G. M. Calaf, Ryeom S, Narayanan KB, A. Lasfar, Brunborg, Gunnar, Sarah N. Bay, P. Heneberg, Castellino, R., Sun J, P. A. Marignani, R. Mehta, Goodson, W., Sabbisetti, V, Ab. Hamid, Hasiah, Williams, Graeme P., Thomas Sanderson, Castellino, RC, Wade M, Robey, R. Brooks, Hu, Zhiwei, Roy, R., W.Kimryn Rathmell, Laird, D., Lleonart ME, William K. Decker, Tae-Jin Lee, Williams, M., D'Abronzo, Leandro S., Wagemaker G, C. Blanco Aparicio, Williams, MA, Romano, S, Hultman, T, Luanpitpong, Sudjit, Zhou, Binhua P., K. A. Cohen Solal, Darroudi, Firouz, Goodson, WH, Williams, Marc A., D’Abronzo, S. Leandro, Marongiu, F., Hamid, Hasiah Ab, Olsen, A. K., Cohen Solal, Karine A., Paul Dent, Hamid, R., Scovassi, A.I., Lee, T. J., Rojas, E., Langie SA, G. S. Goldberg, Roslida A. Hamid, Martin, F.L., Ivana Scovassi, A., Gulliver, L, Kondoh, Hiroshi, Whitfield, J.R., Stefano Forte, Kuemmerle NB, Goodson, W. H., Hsu, C., Simona Romano, Heneberg, P, Charles, Amelia K., van Larebeke N, de Cerain Salsamendi, AL, Marignani, Paola A., Vondráček, Jan, N. Cruickshanks, Weisz, J., Thompson, P, Karamouzis MV, Brown, DG, Wilhelm Engström, Romano, M. F., Otsuki, Takemi, Hsu, Chia Wen, N. Ahmed, R. C. Castellino, R. Abd Hamid, Casey, Stephanie C, E. Corsini, Khatami M, Chen, Tao, Gilbertson, M., Martinez Leal, J., Leyns, L., Amedei A, Papagerakis, Silvana, Sanderson, T., Park, H.H., D'Abronzo, Leandro S, Michalis V. Karamouzis, Kuemmerle, N. B., T. Massfelder, Kirsch-Volders, M, Marongiu, F, S. Romano, Carnero, A., Klaunig, J. E., Barclay, Barry J, Engström, W., Decker, William K, Ab Hamid, H, Sinha, Ranjeet K, Dustin G. Brown, Lee, Tae-Jin, E. Rojas, Ivana Scovassi, A, Vaccari M, Lleonart, M., Prudhomme, Kalan R, Stephanie C. Casey, Darroudi, F, Lee, T-J, Goldberg, Gary S., V. Maguer Satta, Al Mulla, F., Odero Marah, Valerie, Dormoy, Valérian, Maguer Satta, V., P. K. Krishnakumar, Engström W, Olsen, A., Dornetshuber-Fleiss, Rita, Ryeom, S., Kleinstreuer, N, Charles, AK, McCawley, J. Lisa, Wise, SS, Salem, Hosni K., Ogunkua, O., Chen, T., Casey, Stephanie C., David O. Carpenter, T. Otsuki, Cohen-Solal, Karine A., Roy, D, F. J. Van Schooten, Olsen, AK, Lin, Liang-Tzung, L. S. D'Abronzo, Curran CS, Carolyn J. Baglole, Brown, D.G., Al-Mulla, Fahd, Miousse, Isabelle R, Koturbash, I, Krishnakumar, P.K., Robey RB, Roy, R, Rojanasakul, Y., T. Guarnieri, Collins, Andrew Richard, Amedei, A, Darbre, P, Zhiwei Hu, V. Odero Marah, Kim Lyerly, H., Maguer Satta V, Pratima Nangia-Makker, Thompson, Patricia A, L. Zhang, Khatami, Mahin, Lowe, L, Kleinstreuer, N., Zhang, L, Papagerakis S, K. B. Narayanan, Eriksson S, Miousse IR, J. Kravchenko, William H. Bisson, D’Abronzo, Leandro S., Nahta, Rita, J. Vondráček, Baglole, J. Carolyn, Felsher, D. W., Nangami, G.N., V. Sabbisetti, Karine A. Cohen-Solal, M. Gilbertson, Nangami GN, Valerie Odero-Marah, Ostrosky-Wegman, Patricia, Williams, M.A., Wolf GT, Ponce Cusi, Richard, Romano S, Karamouzis, M. V., Adela Lopez de Cerain Salsamendi, D'Abronzo LS, Soucek, Laura, Romano, M.F, Hamid, R. A., Judith Weisz, G. Brunborg, Wise, S., Dormoy V, Cohen Solal, K., Klaunig, James E, Charles, A., M. Khatami, Eriksson, S, Moorwood K, Whitfield, R. Jonathan, Michael Gilbertson, Firouz Darroudi, Jun Sun, Pankaj Vadgama, Rathmell, WK, Zhou, Binhua P, Lleonart, E. Matilde, Koch, D., Wise SS, Sabine A.S. Langie, Koch, DC, Dornetshuber Fleiss, Rita, Hsue-Yin Hsu, Wagemaker, G, Andrade Vieira, R., A. Berg, Wise, J. P., Langie, Sabine a S, Christopher JA, Brooks, Samira A, Luanpitpong S, Carpenter, D. O., J. Weisz, Klaunig, E. James, Koch, Daniel C., Neetu Singh, Raju J, Carpenter, David O, W. K. Rathmell, S. C. Casey, Brooks SA, Martinez Leal JF, Corsini, E, Robey, RB, Brooks Robey, R., S. Eltom, Brunborg G, J. Woodrick, D. J. Carlin, Wolf, G. T., Karamouzis, M., Miousse, Isabelle R., Masoud H. Manjili, Sone, H, Martin, Francis Luke, Charles AK, Valverde, Mahara, Wagemaker, G., Ahmed N, Cruickshanks, N, H. Kim Lyerly, Barclay BJ, Martinez Leal, J. F., M. Lleonart, Vondrá ček, Jan, Castellino, C. Robert, Leyns, L, Hsu HY, Lleonart, Matilde, Whitfield, Jonathan R., Zhenbang Chen, C. J. Baglole, Kirsch Volders M, Mccawley, L., Roman, Jesse, Chiaradonna, F., Dean W. Felsher, Q. S. Cheng, Moon, Eun Yi, Eltom, Sakina E, Krishnan H, P. Darbre, Thierry Massfelder, Koch, C. Daniel, Karamouzis, MV, Vondráček, J., Decker, W. K., Khatami, M, Al Temaimi, Rabeah, Wolf, Gregory T, Gilbertson, M, Carnero, A, Bay, Sarah N., Scovassi, A. Ivana, Bisson, WH, Ryan, E., Kleinstreuer N, Aparicio, Carmen Blanco, Schooten, Frederik J. Van, Salem, HK, Salem, H., Maguer-Satta, Veronique, Colacci, A., E. Laconi, Koturbash I, Moon, E.Y., R. Al Temaimi, Di Fiore, Riccardo, Hamid, Roslida Abd, Juan Fernando Martinez-Leal, Moon, E-Y, Hsu, H.Y., Martin, Francis L, Tae, Jin Lee, Cheng QS, Carmen Blanco-Aparicio, Ryan, EP, Le Jian, Brunborg, G., Manaf Ali, A, Bisson, W., Brown DG, Mehta, Rekha, Al Temaimi, R., Nik van Larebeke, Luqmani, Y., Kravchenko, J, Ratovitski, E, Gonzalez Guzma, Michael J., B. P. Zhou, Laetitia Gonzalez, Naus CC, M. Kirsch Volders, M. Wade, Engström, W, Moon, E., Cheng, Q., Kim Lyerly, H, Wise, J., Kuemmerle, NB, R. Nahta, A. Carnero, Van Schooten, Frederik J, Olugbemiga Ogunkua, Rojanasakul, Y, Sing Leung, Po, Koch DC, Curran, CS, Singh N, Salem, K. Hosni, Langie, SAS, Xia, Menghang, Abdul Manaf Ali, Luanpitpong, S., Patricia Ostrosky-Wegman, Ferdinando Chiaradonna, Darbre P, S. Ryeom, K. R. Prudhomme, William H. Goodson, Nahta, R., Abd Hamid R, Blanco-Aparicio, C, Chiaradonna, Ferdinando, Wade, Mark, Lopez de Cerain Salsamendi A, E. P. Ryan, Moon, E. Y., Sun, J., Maguer-Satta, V, Wise, JP, Ghosh, P. M., Manjili MH, Calaf, Gloria M., Arthur Berg, Wise, S. Sandra, Rafaela Andrade-Vieira, Collins, R. Andrew, Nichola Cruickshanks, Mehta, R, Martin, FL, Castellino, Robert C., Roy, Rabindra, Laura Soucek, Harris, SA, Igor Koturbash, Eun, Yi Moon, Luc Leyns, Chen, Z, Nangia-Makker, Pratima, Philippa Darbre, S. A. S. Langie, Mccawley, Lisa J, Chen, T, Curran, C., Harris, S., Christopher, Joseph A, Barclay, B. J., Mark Wade, Moon, EY, Fahd Al-Mulla, P. Thompson, Cruickshanks, N., Martin, F., Collins AR, Williams MA, Lorenzo Memeo, Danielle J. Carlin, Cheng, QS, Andrade-Vieira, Rafaela, Chia-Wen Hsu, Woodrick J, Mondello, C, Marongiu, Fabio, Manaf Ali, Abdul +999 morecore +1 more sourceClinical Models to Compare the Safety and Efficacy of Inhaled Corticosteroids in Patients with Asthma
Canadian Respiratory Journal, 2003 There is no consensus on the methods to compare the clinical efficacy of different inhaled corticosteroids. A comparison needs to be made in terms of relative potency, and studies should include two-, or preferably, three-dose comparisons.Krishnan Parameswaran, Richard Leigh, Paul M O'Byrne, Margaret M Kelly, Charlie H Goldsmith, Frederick E Hargreave, Myrna Dolovich +6 moredoaj +1 more sourceArtemisinin resistance in Plasmodium falciparum malaria. [PDF]
, 2009 BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam +22 morecore +1 more sourceLongitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht +14 morewiley +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more source
