Aging Cell, 2016 Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on ...
David Desjardins +8 more
semanticscholar +1 more source
Sequential dose-dense single agent chemotherapy for locally advanced breast cancer [PDF]
Archive of Oncology, 2003 Chemotherapy of breast cancer is still the area of intensive research. Based on mathematical model of tumor cell growth kinetics, articulated by Larry Norton, novel concept of chemotherapy in breast cancer was launched and it implies dose-densification ...
Vrbić Svetislav +3 more
doaj +1 more source
Exposure-Response Relationship of Tranexamic Acid in Cardiac Surgery.
Anesthesiology, 2020 BACKGROUND It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery (total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose, approximately 20 mg/kg), particularly as tranexamic acid-associated ...
P. Zufferey +5 more
semanticscholar +1 more source
Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: The influence of gender and comedication [PDF]
Vojnosanitetski Pregled, 2015 Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the
Rančić Nemanja +6 more
doaj +1 more source
Antibiotics, 2022 Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development.
Laiz Campos Pereira +5 more
doaj +1 more source
Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy. [PDF]
, 2002 In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly.
Armstrong, S +10 more
core +2 more sources
Targeted randomization dose optimization trials enable fractional dosing of scarce drugs.
PLoS ONE, 2023 Administering drug at a dose lower than that used in pivotal clinical trials, known as fractional dosing, can stretch scarce resources. Implementing fractional dosing with confidence requires understanding a drug's dose-response relationship.
Philip S Boonstra +2 more
doaj +1 more source
Evaluation of the anticoagulant effect of vitamin K antagonists in patients with non-valvular atrial fibrilation [PDF]
Vojnosanitetski Pregled, 2020 Background/Aim. Despite the introduction of new oral anticoagulants (dabigatran, rivoroxaban, apixaban), vitamin K antagonists (VKA), such as warfarin and acenocoumarol are still the most widely used oral anticoagulants for the treatment of nonvalvular ...
Stanojković Zoran +6 more
doaj +1 more source
Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy [PDF]
, 2011 Background: Nonadherence is very common among subjects undergoing pharmacotherapy for schizophrenia and depression. This study aimed to evaluate the performance of the ratio of the nonlinear mixed effects pharmacokinetic model predicted concentration to ...
Bies, RR +5 more
core +2 more sources
Mathematical modeling and dynamical analysis of anti-tumor drug dose-response
Mathematical Biosciences and Engineering, 2022 Cancer is a serious threat to human health and life. Using anti-tumor drugs is one of the important ways for treating cancer. A large number of experiments have shown that the hormesis appeared in the dose-response relationship of various anti-tumor ...
Yuyang Xiao, Juan Shen, Xiufen Zou
doaj +1 more source