A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]
, 2007 We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross +2 more
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Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: The influence of gender and comedication [PDF]
Vojnosanitetski Pregled, 2015 Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the
Rančić Nemanja +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen +7 more
doaj +1 more source
Evaluation of the anticoagulant effect of vitamin K antagonists in patients with non-valvular atrial fibrilation [PDF]
Vojnosanitetski Pregled, 2020 Background/Aim. Despite the introduction of new oral anticoagulants (dabigatran, rivoroxaban, apixaban), vitamin K antagonists (VKA), such as warfarin and acenocoumarol are still the most widely used oral anticoagulants for the treatment of nonvalvular ...
Stanojković Zoran +6 more
doaj +1 more source
Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]
, 2018 During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey +40 more
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A strategy to model nonmonotonic dose-response curve and estimate IC50. [PDF]
PLoS ONE, 2013 The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic ...
Hui Zhang +3 more
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Mathematical modeling and dynamical analysis of anti-tumor drug dose-response
Mathematical Biosciences and Engineering, 2022 Cancer is a serious threat to human health and life. Using anti-tumor drugs is one of the important ways for treating cancer. A large number of experiments have shown that the hormesis appeared in the dose-response relationship of various anti-tumor ...
Yuyang Xiao, Juan Shen, Xiufen Zou
doaj +1 more source
Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice [PDF]
, 2018 RATIONALE: Drug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history
Grahame, Nicholas J., Houck, Christa A.
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eJournal of Oral Maxillofacial Research, 2022 Objectives: This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up ...
Malihe Karrabi, Zahra Baghani
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Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]
, 2016 Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M. +2 more
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