Results 81 to 90 of about 925,610 (310)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy. [PDF]

, 2020
Intraperitoneal vancomycin is the first-line therapy in the management of peritoneal dialysis (PD)-related peritonitis. However, due to the paucity of data, vancomycin dosing for peritonitis in patients on automated peritoneal dialysis (APD) is empiric ...
Kraft, Walter K., Lam, Edwin, Lien, Yi Ting Kayla, Piraino, Beth, Schmidt, Stephan, Vozmediano, Valvanera, Zhang, Jingjing   +6 more
core   +1 more source

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study. [PDF]

, 2017
Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse.
Bivalacqua, Trinity J, Boorjian, Stephen A, Boyd, Alan, Canter, Daniel J, Dinney, Colin P N, Downs, Tracy M, Gomella, Leonard G, Gregory, Gillian, Grubb, Robert L, Inman, Brant A, Kamat, Ashish M, Karsh, Lawrence I, Krupski, Tracey L, Lerner, Seth P, Lotan, Yair, Milowsky, Matthew I, Ogan, Kenneth, Parker, Nigel R, Sawutz, David G, Shore, Neal D, Svatek, Robert S, Treasure, F Peter, Woods, Michael E, Yla-Herttuala, Seppo   +23 more
core   +2 more sources

A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development

Journal of Pharmacokinetics and Pharmacodynamics, 2023
Exposure–response (E–R) analyses are an integral component in the development of oncology products. Characterizing the relationship between drug exposure metrics and response allows the sponsor to use modeling and simulation to address both internal and ...
A. Ruiz-Garcia, P. Baverel, D. Bottino, M. Dolton, Yan Feng, Ignacio González-García, Jaeyeon Kim, Seth Robey, Indrajeet Singh, David Turner, Shufang Wu, D. Yin, Di Zhou, Hao Zhu, P. Bonate   +14 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours [PDF]

, 2015
BACKGROUND: Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs.
Anneliese Stell, C Martin, D Hochhauser, David E. Thurston, DH Thamm, H Femke, I Puzanov, J Wu, JA Hartley, JA Hartley, JM Dobson, JM Reid, John A. Hartley, JP Banath, K Inoue, KM Rahman, KM Rahman, L Roizin-Towle, Maria Mellinas-Gomez, Matthew Robson, MC Alley, MS Kent, OA Sedelnikova, P Workman, PH Clingen, PJ Bergman, PL Olive, PN Olson, R. Barbara Pedley, RT Bronson, S Arnould, SA Buhrow, SJ Gregson, Solange R. Paredes-Moscosso, Stephen J. Baines, Victoria J. Spanswick, VJ Spanswick, WB Looney, YY Janjigian   +38 more
core   +1 more source

Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose–response curves in mice [PDF]

PeerJ, 2016
Background. Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life.
Raghda A.M. Salama, Nesreen H. El Gayar, Sonia S. Georgy, May Hamza   +3 more
doaj   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source