Results 231 to 240 of about 11,936,984 (295)

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Hesperidin reduces genomic instability in glioblastoma cells and is associated with reduced HNRNPA2B1/m⁶A levels. [PDF]

Front Pharmacol
Sazonova V, Zun P, Tonkji I, Onikienko S, Erofeeva T, Basharin V, Zhigalova N, Ilyushkina A, Skorb E, Ruzov A, Shityakov S, Kravtsov V.   +11 more
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

The role of particle therapy in the treatment of locally recurrent rectal cancer: a systematic review. [PDF]

Radiol Oncol
Perpar A, Georg P, Ermenc AS.
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Application of a low-cost Geiger-Müller monitoring system for clinical radiation environments. [PDF]

J Appl Clin Med Phys
Choi J, Rim CH, Kim H, Lee W.
europepmc   +1 more source

Calculation of the Increase in Dose Rate Due to Precipitation at the Bilbao Radiological Station of the Basque Country Radiological Surveillance Network. [PDF]

Sensors (Basel)
Alegría N, Hernández-Ceballos MÁ, Peñalva I, Legarda F.   +3 more
europepmc   +1 more source

Effects of materials and beam currents on ozone generation in proton beam irradiation: a phantom study. [PDF]

J Radiat Res
Kim T, Lee SB, Kim JY, Kim TH, Moon SH, Park B, Lee KW.   +6 more
europepmc   +1 more source

Radiotherapy-Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments. [PDF]

MedComm (2020)
Ma X, Zhang X, Zhao P, Yang J, Li Z, Han X, Wang Y, Cui Z, Liu N, Li M.   +9 more
europepmc   +1 more source

Peripheral Blood Transcriptomic Profile Associated with Cutaneous Radiation Injury in Cancer Patients Undergoing Radiotherapy. [PDF]

Int J Mol Sci
Muhie S, Chakraborty N, Patel M, Ross A, Moffatt L, McLawhorn M, Gautam A, Shupp J, Hammamieh R.   +8 more
europepmc   +1 more source