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THE DOSE‐RESPONSE RELATIONSHIP OF TUMORIGENESIS BY ULTRAVIOLET RADIATION OF 254 nm
Photochemistry and Photobiology, 1988Abstract— Groups of albino hairless mice, Skh‐hrl, were exposed daily to UVC radiation from low pressure Hg arcs (Philips TUV 40W). These lamps emit predominantly radiation of 254 nm. Three groups of animals were used in the experiments, each receiving a different daily dose.The results were described with the Weibull probability function.
Sterenborg, H. J. +2 more
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A method to adjust radiation dose–response relationships for clinical risk factors
Radiotherapy and Oncology, 2012Several clinical risk factors for radiation induced toxicity have been identified in the literature. Here, we present a method to quantify the effect of clinical risk factors on radiation dose-response curves and apply the method to adjust the dose-response for radiation pneumonitis for patients with/without pre-existing pulmonary co-morbidities.
Appelt, Ane Lindegaard, Vogelius, Ivan R
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Radiotherapy and Oncology, 2010
To evaluate dosimetric factors predictive for radiation-induced pneumonitis (RP) after pulmonary stereotactic body radiotherapy (SBRT).A retrospective analysis was performed based on 59 consecutive patients treated with cone-beam CT-based image-guided SBRT for primary NSCLC (n=21) or pulmonary metastases (n=54).
Matthias, Guckenberger +7 more
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To evaluate dosimetric factors predictive for radiation-induced pneumonitis (RP) after pulmonary stereotactic body radiotherapy (SBRT).A retrospective analysis was performed based on 59 consecutive patients treated with cone-beam CT-based image-guided SBRT for primary NSCLC (n=21) or pulmonary metastases (n=54).
Matthias, Guckenberger +7 more
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Influence of Microdosimetric Quantities on Observed Dose-Response Relationships in Radiation Therapy
Radiation Research, 1990The steepness of dose-response curves in radiation therapy depends to a large extent on the statistics of cell killing. This is so if the last few clonogenic tumor cells have to be hit or eradicated by other means to cure the patient. The steepness is dependent on the number of clonogenic cells in the tumor and the possible variation in their ...
L, Lindborg, A, Brahme
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Radiation dose-response relationships
2018Clinical radiobiology is a field of medical research concerned with the relationship between a given physical absorbed dose of radiation in the range used for cancer therapy and the resulting biological response in a human as well as with the factors that influence this relationship. What is seen in clinical practice is a broad range of doses where the
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Mechanisms and dose-response relationships for radiation-induced cardiovascular disease
Annals of the ICRP, 2012Epidemiological studies have shown a clear association between therapeutic doses of thoracic irradiation and increased risk of cardiovascular disease in long-term cancer survivors. Survivors of Hodgkin's lymphoma and childhood cancers, for example, show 2- to >7-fold increases in risk of cardiac death after total tumour doses of 30–40 Gy, given in ...
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Environmental and Molecular Mutagenesis, 1994
AbstractMicronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy.
A F, McFee, S B, Cook, M G, Abbott
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AbstractMicronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy.
A F, McFee, S B, Cook, M G, Abbott
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Dose–Response Relationship for Parathyroid Adenoma after Exposure to Ionizing Radiation in Infancy
Radiation Research, 2002Several authors have suggested that there is an excess risk of hyperparathyroidism, adenomas or hyperplasia after exposure to ionizing radiation. There is still, however, some uncertainty about this association, because these diseases are often asymptomatic and escape clinical detection if not specially searched for.
Erik, Holmberg +4 more
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Dose-response relationship for radiation carcinogenesis in the low-dose region
International Archives of Occupational and Environmental Health, 1994Evidence that low-level radiation substantially enhances the effectiveness of repair mechanisms is summarized. This finding destroys the theoretical basis (there is no other basis) for use of a linear-no threshold dose-response relationship to estimate the cancer risk of exposure to low-level radiation. Such a methodology will exaggerate the risk. This
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Dose-Response Relationship in Radiation Therapy of Advanced Carcinoma of the Colon and Rectum
Radiology, 1972Abstract The effectiveness of different courses of treatment of recurrent or metastatic carcinoma of the colon and rectum with radiation therapy was evaluated in terms of nominal-single-dose-equivalent rets (NSDE). The formula for derivation of the NSDE for each treatment course was easly to apply and fitted well with observed clinical data. It appears
P K, Soleimani +2 more
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