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2014
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
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Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
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2009
In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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Effect of bioavailability on Dose-Response relationships
The American Journal of Medicine, 1984To achieve the goals of drug therapy one must not only select the appropriate drug but also ensure that it is administered in the proper dose. Sufficient drug should be administered to achieve a therapeutic effect, yet not so much as to produce unwanted side effects.
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1985
In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Dose-Response Relationship of a Uricosuric Diuretic
1977Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics.
B T, Emmerson, L, Thompson, K, Mitchell
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Nonparametric Analysis of Dose‐Response Relationships
Annals of the New York Academy of Sciences, 1999Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
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Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
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Dose-response relationship of phototherapy
The Journal of Pediatrics, 1978L Ballowitz, G. Geutler, J. Krochmann
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