Results 261 to 270 of about 1,351,500 (304)
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Dose-response Relationship in Angiotensin Bioassay
Cardiovascular Research, 1968In the albino rat, pressor response to 1–6 ng valine-5-angiotensin II, aspartic β-amide is a function of the logarithmic transformation of the dose of the drug. The latter transformation should be used to delineate dose-response relationship during angiotensin bioassay.
T S, Ing +3 more
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Dose-response relationship in skin sensitization
Food and Chemical Toxicology, 1994The dose-response relationship (challenge phase) of the skin sensitization response was investigated in previously sensitized Hartley guinea pigs. Larger numbers of animals were used per group at the lower doses so that statistically significant observations could be made.
R L, Bronaugh, C D, Roberts, J L, McCoy
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2014
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
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Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
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Dose-Response Relationships for Meningioma Radiosurgery
American Journal of Clinical Oncology, 2015Dose-response relationships for meningioma radiosurgery are poorly characterized. We evaluated determinants of local recurrence for meningiomas treated with Gamma Knife radiosurgery (GKRS), to guide future treatment approaches to optimize tumor control.A total of 101 consecutive patients (108 tumors) who underwent GKRS for benign, atypical, or ...
Rajni A, Sethi +9 more
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1987
One of the most powerful tools in the analysis of toxicological events is the description of the intensity of the exposure in terms of dose, dose rate, or concentration for a specified duration of exposure in relation to the frequency or intensity of the observed responses.
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One of the most powerful tools in the analysis of toxicological events is the description of the intensity of the exposure in terms of dose, dose rate, or concentration for a specified duration of exposure in relation to the frequency or intensity of the observed responses.
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Assessment of a dose–response relationship of levetiracetam
European Journal of Neurology, 2006The aim of this study was to assess the relationship between levetiracetam dose and both efficacy and safety in adult patients with refractory partial epilepsy. Dose–response relationships for levetiracetam efficacy were evaluated using pooled data from three trials including adults with refractory partial epilepsy.
H-J, Meencke, S, Buyle
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LEAD AND MORBIDITY: A DOSE-RESPONSE RELATIONSHIP
The Lancet, 1978Many laboratory tests have been recommended for monitoring factory workers exposed to lead. To select the most useful test the best predictor of selected measures of morbidity was sought. 639 lead-exposed workers in several factories were questioned about abdominal ache, constipation, and fatigue and were examined for hand tremot.
L M, Irwig +4 more
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2009
In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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1985
In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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Effect of bioavailability on Dose-Response relationships
The American Journal of Medicine, 1984To achieve the goals of drug therapy one must not only select the appropriate drug but also ensure that it is administered in the proper dose. Sufficient drug should be administered to achieve a therapeutic effect, yet not so much as to produce unwanted side effects.
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