Results 271 to 280 of about 1,351,500 (304)
Some of the next articles are maybe not open access.
Nonparametric Analysis of Dose‐Response Relationships
Annals of the New York Academy of Sciences, 1999Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
openaire +2 more sources
Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
openaire +2 more sources
Dose-Response Relationship of a Uricosuric Diuretic
1977Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics.
B T, Emmerson, L, Thompson, K, Mitchell
openaire +2 more sources
Dose-response relationship in clinical oncology
Plastic and Reconstructive Surgery, 1985The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment ...
openaire +2 more sources
Dose-response relationship of phototherapy
The Journal of Pediatrics, 1978L Ballowitz, G. Geutler, J. Krochmann
openaire +2 more sources
Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
openaire +1 more source
openaire +1 more source
Dose-response relationships in carcinogenesis.
IARC scientific publications, 1992Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view.
D, Krewski, M J, Goddard, J M, Zielinski
openaire +1 more source