Results 301 to 310 of about 1,339,184 (328)

Dose-Response Relationships

Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
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Modeling Dose-Response Relationships

1997
Theories of the effects of the environment on health are founded on the axiom that each state of health is reached through a series of changes in the body which may be identified as distinct stages1. A particular health effect, therefore, requires several changes in the cells, tissues or organs of the body, and often requires doses from several ...
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Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Dose-response relationship for supraglottic laryngeal carcinoma

International Journal of Radiation Oncology*Biology*Physics, 1983
In this editorial, two important issues in the treatment of cancers of the supraglottic larynx which had been raised by other authors, Harwood et al., are discussed. The first is the technique of elective irradiation of clinically uninvolved neck nodes.
L J, Peters, H D, Thames
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Nonparametric Analysis of Dose‐Response Relationships

Annals of the New York Academy of Sciences, 1999
Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
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Dose-response relationship in clinical oncology

Plastic and Reconstructive Surgery, 1985
The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment ...
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Radiation dose-response relationships

2018
Clinical radiobiology is a field of medical research concerned with the relationship between a given physical absorbed dose of radiation in the range used for cancer therapy and the resulting biological response in a human as well as with the factors that influence this relationship. What is seen in clinical practice is a broad range of doses where the
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Dose-Response Relationship

2023
John Timbrell, Frank A. Barile
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Estrogen dose-response relationship

Clinical Pharmacology and Therapeutics, 1987
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Dose-response relationships in carcinogenesis.

IARC scientific publications, 1992
Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view.
D, Krewski, M J, Goddard, J M, Zielinski
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