Results 311 to 320 of about 1,297,078 (335)
Some of the next articles are maybe not open access.
Modeling Dose-Response Relationships
1997Theories of the effects of the environment on health are founded on the axiom that each state of health is reached through a series of changes in the body which may be identified as distinct stages1. A particular health effect, therefore, requires several changes in the cells, tissues or organs of the body, and often requires doses from several ...
openaire +2 more sources
Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
openaire +2 more sources
CNS Drugs, 2008
Quetiapine is a widely used second-generation antipsychotic that is effective in the treatment of schizophrenia and bipolar mania. In recent years, various publications have suggested the possibility that, in some patients, higher than licensed dosages are necessary for full therapeutic effect. A 'high-dose' theory of quetiapine activity has developed,
Anna Sparshatt +2 more
openaire +2 more sources
Quetiapine is a widely used second-generation antipsychotic that is effective in the treatment of schizophrenia and bipolar mania. In recent years, various publications have suggested the possibility that, in some patients, higher than licensed dosages are necessary for full therapeutic effect. A 'high-dose' theory of quetiapine activity has developed,
Anna Sparshatt +2 more
openaire +2 more sources
Effect of bioavailability on Dose-Response relationships
The American Journal of Medicine, 1984To achieve the goals of drug therapy one must not only select the appropriate drug but also ensure that it is administered in the proper dose. Sufficient drug should be administered to achieve a therapeutic effect, yet not so much as to produce unwanted side effects.
openaire +3 more sources
Assessment of the dose-response relationship of Campylobacter jejuni
International Journal of Food Microbiology, 1996Mathematical relations describing the risk of infection after exposure to enteropathogens are important tools for the evaluation of the potential health risk from exposure via food and water. A quantitative description of the dose-response relation for Campylobacter jejuni with the Beta-Poisson model was fitted to experimental data of infection with ...
Medema, GJ +3 more
openaire +4 more sources
Dose-Response relationship of a tumor-promoting agent*1
Toxicology and Applied Pharmacology, 1960Abstract The time of appearance of the tumors, and the cumulative response, varied with the dose of a fraction of croton oil which was applied on the initiated skins of mice. The present results have not established a rigorous dose-response relationship; they indicate nevertheless a definite quantitative trend.
John P. Gilbert, Jean Sicé
openaire +3 more sources
Analysis of Dose—Response Relationships
1976The discipline of pharmacology is currently going through an important stage in its development. It is at that point where it is appropriate to begin to shift emphasis from what has been essentially a descriptive approach to one tied to a more general framework.
openaire +2 more sources
Nonparametric Analysis of Dose‐Response Relationships
Annals of the New York Academy of Sciences, 1999Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
openaire +3 more sources
Meta-Analysis of Dose-Response Relationships
2020This chapter explains how to conduct statistical inference on dose-response relationships, describing how a response varies across levels of a quantitative factor, based on tables of data summarized by categorizing the quantitative factor. It provides a flexible framework to conduct a two-stage dose-response meta-analysis. The versatility of regression
Nicola Orsini, Donna Spiegelman
openaire +2 more sources
Dose-response relationship of phototherapy
The Journal of Pediatrics, 1978L. Ballowitz, G. Geutler, J. Krochmann
openaire +3 more sources