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The Dose-Response Relationship of Tranexamic Acid
Anesthesiology, 1995Background Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after cardiac operations. However, the best dose of tranexamic acid for this purpose remains unknown. This study explored the dose-response relationship of tranexamic acid for hemostatic efficacy after cardiac
Michael D. Strong +4 more
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Dose-Response Relationship in Radiation Leukæmia
Nature, 1959A SIGNIFICANT contribution is achieved by Drs. Armitage, Court Brown and Doll in evaluating some models postulated in assessing the leukaemogenic potency of radiations. Along this line, it appears relevant to discuss some possible interpretations of a linear dose-response, observed over a limited range of leukaemia incidence, as evidenced in the study ...
P, ARMITAGE +3 more
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Dose-Response Relationship With Venlafaxine
Journal of Clinical Psychopharmacology, 1996Considerations when selecting a first-line antidepressant agent include the potential for achieving greater response with increasing dosages, thereby allowing greater flexibility in dosing. The efficacy and dose-response of venlafaxine, a novel serotonin and norepinephrine reuptake inhibitor, was evaluated in two placebo-controlled studies.
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Dose-response relationship for trichloroethylene in man
International Archives of Occupational and Environmental Health, 1977Twelve volunteer students were experimentally exposed to 0, 27, 81 or 201 ppm trichloroethylene for 4 hours, and suffered from irritation to mucous membrane of eyes and throat at over 27 ppm trichloroethylene. No headache or physiological responses were reported at 27 ppm; headache occurred at levels over 81 ppm.
Hiroko Nomiyama, Kazuo Nomiyama
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Dose—response relationship in clinical oncology
Cancer, 1984The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment ...
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Dose-response Relationship in Angiotensin Bioassay
Cardiovascular Research, 1968In the albino rat, pressor response to 1–6 ng valine-5-angiotensin II, aspartic β-amide is a function of the logarithmic transformation of the dose of the drug. The latter transformation should be used to delineate dose-response relationship during angiotensin bioassay.
Mitchell Passovoy +3 more
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1987
One of the most powerful tools in the analysis of toxicological events is the description of the intensity of the exposure in terms of dose, dose rate, or concentration for a specified duration of exposure in relation to the frequency or intensity of the observed responses.
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One of the most powerful tools in the analysis of toxicological events is the description of the intensity of the exposure in terms of dose, dose rate, or concentration for a specified duration of exposure in relation to the frequency or intensity of the observed responses.
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Dose-Response Relationships for Meningioma Radiosurgery
American Journal of Clinical Oncology, 2015Dose-response relationships for meningioma radiosurgery are poorly characterized. We evaluated determinants of local recurrence for meningiomas treated with Gamma Knife radiosurgery (GKRS), to guide future treatment approaches to optimize tumor control.A total of 101 consecutive patients (108 tumors) who underwent GKRS for benign, atypical, or ...
R.A. Sethi +9 more
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Assessment of a dose–response relationship of levetiracetam
European Journal of Neurology, 2006The aim of this study was to assess the relationship between levetiracetam dose and both efficacy and safety in adult patients with refractory partial epilepsy. Dose–response relationships for levetiracetam efficacy were evaluated using pooled data from three trials including adults with refractory partial epilepsy.
S. Buyle, H.-J. Meencke
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Dose-Response Relationship of a Uricosuric Diuretic [PDF]
, 1977 Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics.
Bryan T. Emmerson +2 more
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