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Dose–Response Relationship

2014
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
Choo Hock Tan
semanticscholar   +3 more sources

Dose-response relationships for carcinogens

Toxicology Letters, 1995
Biotransformation of chemical carcinogens involves both metabolic activation and detoxication. The molecular dose present on DNA as adducts represents a balance between these two pathways (formation) and DNA repair. All of these are enzymatic processes subject to saturation. When none of the pathways is saturated, linear molecular dosimetry is expected,
J A, Swenberg   +3 more
openaire   +2 more sources

Dose-Response Relationship With Venlafaxine

Journal of Clinical Psychopharmacology, 1996
Considerations when selecting a first-line antidepressant agent include the potential for achieving greater response with increasing dosages, thereby allowing greater flexibility in dosing. The efficacy and dose-response of venlafaxine, a novel serotonin and norepinephrine reuptake inhibitor, was evaluated in two placebo-controlled studies.
openaire   +2 more sources

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