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Dose-response relationship in skin sensitization
Food and Chemical Toxicology, 1994The dose-response relationship (challenge phase) of the skin sensitization response was investigated in previously sensitized Hartley guinea pigs. Larger numbers of animals were used per group at the lower doses so that statistically significant observations could be made.
R L, Bronaugh, C D, Roberts, J L, McCoy
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1985
In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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Effect of bioavailability on Dose-Response relationships
The American Journal of Medicine, 1984To achieve the goals of drug therapy one must not only select the appropriate drug but also ensure that it is administered in the proper dose. Sufficient drug should be administered to achieve a therapeutic effect, yet not so much as to produce unwanted side effects.
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Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Dose-Response Relationship of a Uricosuric Diuretic
1977Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics.
B T, Emmerson, L, Thompson, K, Mitchell
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Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
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Nonparametric Analysis of Dose‐Response Relationships
Annals of the New York Academy of Sciences, 1999Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
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Dose-response relationship of phototherapy
The Journal of Pediatrics, 1978L Ballowitz, G. Geutler, J. Krochmann
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Dose-response relationship in clinical oncology
Plastic and Reconstructive Surgery, 1985The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment ...
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