Results 161 to 170 of about 5,610,097 (285)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Prognostic impact of corticosteroid maintenance dose and re-escalation in patients with cardiac sarcoidosis. [PDF]

Open Heart
Nishimura T, Ishibashi K, Kanaoka K, Nakajima K, Ikee T, Syako D, Nakamura T, Oka S, Wakamiya A, Ueda N, Kamakura T, Wada M, Inoue Y, Miyamoto K, Aiba T, Kusano K.   +15 more
europepmc   +1 more source

Thermal dose and thermal isoeffect dose [PDF]

International Journal of Hyperthermia, 1989
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Modeling, Simulation, and Extrapolation to Optimize Pediatric Development Plan: Sarilumab Polyarticular-Course juvenile arthritis Application. [PDF]

J Pharmacokinet Pharmacodyn
Xu C, Zhang M, Liu Y, Baret-Cormel L, De Benedetti F, Abdallah H, Kanamaluru V, Meng Z.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence, spatial patterns and determinants of zero-dose vaccination among children aged 12-23 months in Sub-Saharan Africa: A multilevel spatial analysis. [PDF]

PLoS One
Tamir TT, Agimas MC, Angaw DA.
europepmc   +1 more source

[Equivalent dose or dose equivalence?].

Arhiv za higijenu rada i toksikologiju, 1994
In the Croatian language the terms denoting certain physical quantities in the field of radiation protection dosimetry lack precision. Consequently, either the English expressions or mathematical formulas are used instead. The situation is even worse as only a limited number of textbooks, reference books and professional papers are available in the ...
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Paracetamol prescriptions in older people hospitalized in a French geriatric hospital

Health Science Reports, 2023
Frederic Baud, Nadia Ladjouzi, Jihène Ben Hassen, Nesrine El Omeiri, Hendriniainia Raveloson, Lucile Brondin, Camille Ben Rahal, Cid Ould Ouali, Georges Zouloumis, Joël Schlatter   +9 more
doaj   +1 more source