Results 51 to 60 of about 10,586,048 (306)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparing Radiation Doses in CBCT and Medical CT Imaging for Dental Applications

Journal of Pharmacy and Bioallied Sciences
BackgroundDental imaging plays a crucial role in diagnosis and treatment planning, with cone-beam computed tomography (CBCT) and medical computed tomography (CT) being two common modalities.
Jain Sulabh, Sarah, Mishra Shweta, Saleem Sumera, Vijayan Anu   +4 more
doaj   +1 more source

Diagnostic Reference Levels in Interventional Pediatric Cardiology: Two-Year Experience in a Tertiary Referral Hospital in Latin America

Children, 2023
The goal of the present study was to propose the first local diagnostic reference levels (DRLs) for interventional pediatric cardiology procedures in a large hospital in Colombia. The data collection period was from April 2020 to July 2022.
Ana M. Aristizabal, Jaiber A. Gutiérrez, Emmanuel Ramirez, Valentina Mejía-Quiñones, Carlos Ubeda, Walter Fernando Mosquera, Walter Mosquera   +6 more
doaj   +1 more source

A simple method to retrospectively estimate patient dose-area product for chest tomosynthesis examinations performed using VolumeRAD.

Medical Physics (Lancaster), 2014
PURPOSE The purpose of the present work was to develop and validate a method of retrospectively estimating the dose-area product (DAP) of a chest tomosynthesis examination performed using the VolumeRAD system (GE Healthcare, Chalfont St.
M. Båth, Christina Söderman, A. Svalkvist   +2 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimization and audit of radiation dose during percutaneous transluminal coronary angioplasty

Journal of Medical Physics, 2007
The percutaneous transluminal coronary angioplasty (PTCA) is one of the interventional procedures which impart high radiation doses to patients compared to the other cardiologic procedures. This study intends to audit and optimize radiation dose imparted
Livingstone Roshan, Timothy Peace B, Chandy Sunil, George Paul, Pati Purendra   +4 more
doaj  

Patient Peak Skin Dose and Dose Area Product from Interventional Cardiology Procedures

, 2015
Information about the peak skin dose and Dose Area product (DAP) from percutaneous transluminal coronary angioplasty (PTCA) and coronary angiography (CA) was collected from three catheter application rooms. The range of maximum photon energy was 50 - 125
Antar Aly, I. Duhaini, Samia M. Manaa, Sayed M. Tarique, S. Kuniyil, H. Al Naemi   +5 more
semanticscholar   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dose-area product reduction through a practice implementing low frame rate fluoroscopy and increased collimation during single-vessel percutaneous coronary interventions

Radiation Protection and Environment
This study aims to investigate the impact of lowering fluoroscopic frame rate and increasing collimation on dose area product (DAP) during single-vessel percutaneous coronary interventions.
Christos Bousis, Thanasis Kosovitsas, Pavlos Karanikis, Anna Kotsia, Eleni Tzima, Evgenia Pappa   +5 more
doaj   +1 more source