Results 71 to 80 of about 25,674 (297)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Feasibility of PET/CT system performance harmonisation for quantitative multicentre 89Zr studies

EJNMMI Physics, 2018
Purpose The aim of this study was to investigate the variability in quantitative performance and feasibility of quantitative harmonisation in 89Zr PET/CT imaging.
Andres Kaalep, Marc Huisman, Terez Sera, Danielle Vugts, Ronald Boellaard, on behalf of EARL, EATRIS, the TRISTAN Consortium (#IB4SD-116106)   +7 more
doaj   +1 more source

Is the image quality of I-124-PET impaired by an automatic correction of prompt gammas? [PDF]

PLoS ONE, 2013
OBJECTIVES: The aim of this study is to evaluate the quality of I-124 PET images with and without prompt gamma compensation (PGC) by comparing the recovery coefficients (RC), the signal to noise ratios (SNR) and the contrast to F-18 and Ga-68 ...
Veronika Preylowski, Susanne Schlögl, Frédéric Schoenahl, Gerhard Jörg, Samuel Samnick, Andreas K Buck, Michael Lassmann   +6 more
doaj   +1 more source

The compositional and metabolic responses of gilthead seabream (Sparus aurata) to a gradient of dietary fish oil and associated n-3 long-chain PUFA content [PDF]

, 2017
The authors express their gratitude to the technical team at the BioMar Feed Trial Unit, Hirtshals, in particular, Svend Jørgen Steenfeldt for expert care of the experimental subjects, for training and supervision provided by laboratory staff at ...
Betancor, Mónica B, Houston, Sam J S, Karalazos, Vasileios, Martin, Samuel A M, Monroig, Oscar, Tinsley , John, Tocher, Douglas R   +6 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Differential expression of mTOR signalling components in drug resistance in ovarian cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 The International Institute of Anticancer Research.Background/Aim: A limitation to successful cancer ...
Coley, HM, Foster, H, Goumenou, A, Harvey, AJ, Karteris, E, Pados, G   +5 more
core  

Technical performance and diagnostic utility of the new Elecsys (R) neuron-specific enolase enzyme immunoassay [PDF]

, 2003
This international multicenter study was designed to evaluate the technical performance of the new double-monoclonal, single-step Elecsys neuron-specific enolase (NSE) enzyme immunoassay (EIA) and to assess its utility as a sensitive and specific test ...
Chang SF, Collazos J, Cooper EH, Costongs GMPJ, Ebert W, Ebert W, Ebert W, Ebert W, Fossa SD, Johnson PWM, Jorgensen LGM, Müller KM., Passing H, Rowinska-Zakrzewska E, Schmitt UM, Sterk M, Stieber P, Szturmowicz M, Zeltzer PM   +18 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Clobetasol brazilian pilot study: the vasoconstrictor assay over time [PDF]

Brazilian Journal of Pharmaceutical Sciences
The vasoconstrictor assay (VCA) has been internationally recognized as a reliable method to evaluate the bioequivalence of topical corticosteroids. The FDA has recommended its use since 1995 and ANVISA began to require this assay in 2022 (RDC no. 742/22).
Isabelle Moura Fittipaldi de Souza Dantas Cavalcanti, Irla Carla de França Barbosa, Cristiano Ferraz, Isadore Kanfer, Kelen Carine Costa Soares, Davi Pereira de Santana, Leila Bastos Leal   +6 more
doaj   +1 more source