Results 51 to 60 of about 25,674 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Dose calibration of EPIDs for segmented IMRT dosimetry [PDF]

Journal of Applied Clinical Medical Physics, 2014
The purpose of this study was to investigate the dose response of amorphous silicon (a‐Si) electronic portal imaging devices (EPIDs) under different acquisition settings for both open jaw defined fields and segmented intensity‐modulated radiation therapy (IMRT) fields. Four different EPIDs were used.
Deshpande, S, Xing, A, Holloway, L, Metcalfe, P, Vial, P   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ANALISIS SISA RADIOFARMAKA TC99M MDP PADA PASIEN KANKER PAYUDARA

JIF (Jurnal Ilmu Fisika), 2013
Telah dilakukan analisis sisa radiofarmaka Tc99m MDP pada pasien kanker payudara di salah satu rumah sakit di Jakarta. Dalam penelitian ini digunakan dua alat utama yaitu kamera gamma dan dose calibrator, dengan bahan utama Tc99m MDP yaitu unsur ...
Hajjatun Khairah, Dian Milvita, Dian Fitriyani, Sri Mulyadi   +3 more
doaj   +1 more source

Anti-SARS-CoV-2 Antibodies Within IVIg Preparations: Cross-Reactivities With Seasonal Coronaviruses, Natural Autoimmunity, and Therapeutic Implications

Frontiers in Immunology, 2021
Introduction: Cross-reactivity to SARS-CoV-2 antigenic peptides has been detected on T-cells from pre-pandemic donors due to recognition of conserved protein fragments within members of the coronavirus's family.
Marinos C. Dalakas, Marinos C. Dalakas, Kleopatra Bitzogli, Harry Alexopoulos   +3 more
doaj   +1 more source

Calibration of 192Ir high dose rate brachytherapy source using different calibration procedures [PDF]

Reports of Practical Oncology & Radiotherapy, 2014
To calibrate Ir-192 high dose rate (HDR) brachytherapy source using different calibration methods and to determine the accuracy and suitability of each method for routine calibrations.The source calibration is an essential part of the quality assurance programme for dosimetry of brachytherapy sources.
Bondel, Shwetha, Ravikumar, Manickham, Supe, Sanjay Sudhakar, Reddy, Buchuppudi Rekha   +3 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness [PDF]

, 2015
BackgroundPractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4.
Dhariwal, J, Francombe, G, Gilbert, J, Hansel, TT, Jones, RE, Kitson, J, Kon, OM, Murdoch, R, Nicholson, G, Openshaw, PJ, Tan, AJ, Tunstall, T, Walton, RP   +12 more
core   +11 more sources

Adsorption of Radioactive Materials by Green Microalgae Dunaliella Salina from Aqueous Solution [PDF]

Iranian Journal of Medical Physics, 2019
Introduction: Nuclear accidents release large quantities of radioactive materials into the environment. Iodine-131 and cesium-137 are two radionuclides released during nuclear accident, which can pose the greatest cancer risks. These radionuclides can be
Rasool Azmoonfar, Masoud Najafi, Abolhasan rezaeyan, Ehsan Khodamoradi, Naser Rasouli   +4 more
doaj   +1 more source