Results 61 to 70 of about 25,674 (297)

Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
Forcina, Laura, Musaro', Antonio, Nicoletti, Carmine, Pelosi, Laura, Scicchitano, Bianca Maria   +4 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays

Research and Practice in Thrombosis and Haemostasis, 2021
Background Activated coagulation factor XIa (FXIa) is an impurity and primary source of procoagulant activity in thrombosis‐implicated immune globulin (IG) products.
Yideng Liang, Joseph W. Jackson, Samuel A. Woodle, Stepan S. Surov, Leonid A. Parunov, Dorothy E. Scott, Mark Weinstein, Timothy K. Lee, Mikhail V. Ovanesov   +8 more
doaj   +1 more source

Temperature dependence of the LabPET small-animal PET scanner [PDF]

, 2012
INTRODUCTION In quantitative PET imaging it is important to correct for all image-degrading effects, for example detector efficiency variation. Detector efficiency variation depends on the stability of detector efficiency when operating conditions vary ...
Keereman, Vincent, Van Holen, Roel, Vandenberghe, Stefaan, Vanhove, Christian   +3 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris, Gu, Mei, Lehnert, Hendrik, Markovic, Danijela, Newton, Rob, Slater, Donna, Vatish, Manu   +6 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Feasibility of CT quantification of intratumoural 166Ho-microspheres

European Radiology Experimental, 2020
Background Microspheres loaded with radioactive 166Ho (166Ho-MS) are novel particles for radioembolisation and intratumoural treatment. Because of the limited penetration of β radiation, quantitative imaging of microsphere distribution is crucial for ...
R. C. Bakker, R. Bastiaannet, S. A. van Nimwegen, A. D. Barten-van Rijbroek, R. J. J. Van Es, A. J. W. P. Rosenberg, H. W. A. M. de Jong, M. G. E. H. Lam, J. F. W. Nijsen   +8 more
doaj   +1 more source

Accuracy and precision assessment for activity quantification in individualized dosimetry of 177Lu-DOTATATE therapy [PDF]

, 2017
Background: In order to obtain a reliable 177Lu-DOTATATE therapy dosimetry, it is crucial to acquire accurate and precise activity measurements with the radionuclide calibrator, the SPECT/CT camera, and the NaI(Tl) well counter. The aim of this study was
Flamen, Patrick, Guiot, Thomas, Karfis, Ioannis, Marin, Gwennaëlle, Vandenberghe, Stefaan, Vanderlinden, Bruno, Wimana, Zena   +6 more
core   +2 more sources

Calibration of dose calibrators in the laboratory for radioisotopes [PDF]

, 2022
9th Balkan congress of nuclear medicine, May 12-14, 2022., Vrdnik ...
Stanković, Dragana, Mirković, Marija D., Radović, Magdalena, Janković, Drina, Laban-Božić, Olivera, Matović, Milovan, Jeremić, Marija, Vranješ-Đurić, Sanja   +7 more
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