Results 201 to 210 of about 233,485 (260)

Dose‐dependent prednisolone kinetics

Clinical Pharmacology & Therapeutics, 1979
Kinetic data for prednisolone and prednisone have been determined following oral administration of prednisolone over a dosage range of 5 to 200 mg in 43 subjects. Intravenous studies have been performed at 20 mg and 100 mg in 3 subjects. At all dosage levels the elimination t½β for prednisolone remained constant (t½β 3.5 ± 0.2 hr [20 mg], t½β 3.7 ± 0.1
Tanner A., Bochner F., Caffin J., Halliday J., Powell L.   +4 more
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Dose-dependency of caffeine metabolism with repeated dosing

Clinical Pharmacology & Therapeutics, 1990
Some recent epidemiologic studies have reported a nonlinear dose-response in the relationship between coffee consumption and health risks, such that the risks increase disproportionately to the increase in dose. Assuming caffeine contributes to the adverse health effects of coffee, a possible explanation for the nonlinear dose-response relationship is ...
Denaro, Charles P., Brown, Christopher R., Wilson, Margaret, Jacob, Peyton, Benowitz, Neal   +4 more
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Dose-dependent pharmacokinetics of dexamethasone

European Journal of Clinical Pharmacology, 1986
The dose dependency of the pharmacokinetics of dexamethasone and its influence on the endogenous secretion of cortisol has been studied in healthy females. The maximum plasma level occurred between 1.6 and 2.0 h after doses of 0.5-3.0 mg independent of the type of administration.
D, Loew, O, Schuster, E H, Graul
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Dose-dependence of the pharmacokinetics of quinidine

European Journal of Clinical Pharmacology, 1977
Quinidine was administrated orally to five healthy male volunteers. Doses of 0.2 g t.i.d., 0.3 g t.i.d. and 0.4 g t.i.d. were given for five days with at least four weeks between each test period. The plasma concentration of quinidine was measured before the morning dose on Days 2-5 of treatment, and 1, 2, 4 and 8 h after the morning dose on the 5th ...
P, Bolme, U, Otto
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Dose dependent pharmacokinetics of prednisolone

European Journal of Clinical Pharmacology, 1977
The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight.
M E, Pickup, J R, Lowe, P A, Leatham, V M, Rhind, V, Wright, W W, Downie   +5 more
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Dependence of RBE on neutron dose

The British Journal of Radiology, 1972
In a recent article (Alper, 1972) Dr. Alper states that the relative biological effectiveness, R, of neutrons at high neutron doses, DN, varies as the inverse of DN, provided the dose effect curves are exponential at higher doses. This might be considered to be in contradiction to our finding (Rossi, 1970; Kellerer and Rossi, 1971) that over a wide ...
A M, Kellerer, H H, Rossi
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Dependence on zolpidem in high dose

International Clinical Psychopharmacology, 2000
There are some indications that zolpidem is open to potential abuse. We present four cases of former drug or alcohol abusers with personality disorders, who all developed dependence on zolpidem in high dose.
D, Vartzopoulos, V, Bozikas, C, Phocas, A, Karavatos, G, Kaprinis   +4 more
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Dose Dependence of Piperacillin Pharmacokinetics

Chemotherapy, 2009
Pharmacokinetics were evaluated for piperacillin given as doses of 15, 30 and 60 mg/kg body weight to 12 healthy volunteers subdivided into three groups which were each given different dosage levels. For the 15, 30 and 60 mg/kg doses, the serum half-lives were 0.8, 1.0 and 0.9 hand the disposition phase distribution volume coefficients, Δ<sub>d,β&
T, Bergan, J D, Williams
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Dose‐dependent enzyme induction

Clinical Pharmacology & Therapeutics, 1973
Administration of qUinalbarbitone, 100 mg nightly, caused a fall in steady‐state plasma warfarin concentration ranging from 5% to 64.5% in 6 patients. There was no correlation between the extent of this fall and either the plasma concentration of quinalbarbitone or the initial rate of warfarin metabolism.
A, Breckenridge, M L, Orme, L, Davies, S S, Thorgeirsson, D S, Davies   +4 more
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Dose-dependent atorvastatin associated with angioedema

Int. Journal of Clinical Pharmacology and Therapeutics, 2022
To describe a case of angioedema associated with increasing the dose of HMG-CoA reductase inhibitor (atorvastatin) from 20 to 40 mg daily in a patient previously stable on angiotensin II receptor blocker (losartan) and calcium channel blocker (amlodipine) as antihypertensive agents.A 79-year-old woman with no known drug allergies and a history of ...
Ayman M, Al-Qaaneh, Waleed T, Obaid, Osama S, Al-Mohammadi, Ahmad M, Al-Qaaneh, Ali A, Rabaan, Shadi M, Mustafa   +5 more
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