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Dose-dependent kinetics of theophylline
Journal of Allergy and Clinical Immunology, 1986This article reviews the background and current status of knowledge regarding the nonlinear kinetics of theophylline. The metabolic and renal mechanisms of nonlinearity and their significance with respect to single and multiple doses of theophylline are reviewed.
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Dose-dependent pharmacokinetics of PMM in the rat
Cancer Chemotherapy and Pharmacology, 1981Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 mu g/ml X min; plasma clearances were 0.042 and 0.027 l . kg(-1) . min(-1), respectively.
T, Colombo, L, Torti, M, D'Incalci
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Lack of dose dependent kinetics of theophylline
European Journal of Clinical Pharmacology, 1983Oral theophylline was given to 6 adults with airways obstruction. The initial dose was 125 mg daily and this was increased by 125 mg each week. The final total daily dose reached was determined by side effects and ranged from 500 mg to 1125 mg. At the end of each week and before the next dosage increment steady state, trough plasma theophylline ...
P J, Brown, L J, Dusci, G M, Shenfield
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Dose-dependent kinetics of ethotoin in man
Clinical and Experimental Pharmacology and Physiology, 19751. A gas-chromatographic assay for the anticonvulsant drug ethotoin in plasma has been used to establish a kinetic basis for therapy in eight newly diagnosed epileptic patients. 2. Only a small fraction of ethotoin was excreted unchanged. Elimination curves were only rectilinear below a plasma concentration of 8 mg/l.
O. Sjö +4 more
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Dose-dependent effects of phytoestrogens on bone
Trends in Endocrinology and Metabolism, 2005Phytoestrogens have the potential to maintain bone health and delay or prevent osteoporosis. This review focuses on their dose-dependent effects on bone and their possible mechanisms of action. Phytoestrogens exert biphasic dose-dependent effects on osteoblasts and osteoprogenitor cells, stimulating osteogenesis at low concentrations and inhibiting ...
Zhi Chao, Dang, Clemens, Lowik
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Dose‐dependent pharmacokinetics of furosemide in the rat
Biopharmaceutics & Drug Disposition, 1982AbstractThe pharmacokinetics of furosemide were investigated in the rat at doses of 10 and 40mg kg−1 corresponding to doses of 80 and 320 mg given to humans based on body surface area. A three‐compartment open model with renal excretion taking place from the shallow peripheral compartment gave the best fit to the data.
M M, Hammarlund, L K, Paalzow
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RADIATION‐INDUCED HYPOPITUITARISM IS DOSE‐DEPENDENT
Clinical Endocrinology, 1989SUMMARYRadiation‐induced hypopituitarism has been studied prospectively for up to 12 years in 251 adult patients treated for pituitary disease with external radiotherapy, ranging in dose from 20 Gy in eight fractions over 11 days to 45 Gy in 15 fractions over 21 days.
M D, Littley +4 more
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Dose-dependent Elimination Kinetics of Theophylline
Clinical Pharmacokinetics, 1979There are an increasing number of clinical and experimental studies appearing in the literature suggesting that the elimination kinetics of theophylline may be dose-dependent in man. Evidence of nonlinearity includes observations that steady-state serum theophylline concentrations may increase disproportionately with increases in dose and that the ...
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DOSE DEPENDENCE OF GALACTOSE CATARACT IN THE RAT
Acta Ophthalmologica, 1972Feeding of galactose to albino rats results in the development of subcortical and nuclear cataract. The time for cataract formation was highly correlated with the dose of galactose, the minimum time for development of subcortical cataract being four days and for that of nuclear cataract, 45 days.Nuclear cataract did not develop in any case during the ...
S, Keiding, L, Mellemgaard
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Dopa Dose-Dependent Sexual Deviation
British Journal of Psychiatry, 1983Changes in sexual behaviour in patients with Parkinson's disease treated with levodopa are well recognized. Barbeau (1969) was the first to draw attention to “a clear-cut visually evident increase in libido” occurring in at least four out of 62 male parkinsonian patients treated with levodopa. Hyyppa et al (1970) reported that among 41 treated patients
N P, Quinn +4 more
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