Results 101 to 110 of about 585,390 (295)

Enhancement of Opioid-Mediated Analgesia\ud by Ingestion of Amniotic Fluid:\ud Onset Latency and Duration [PDF]

, 1989
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia produced by morphine injection, footshock, vaginal/cervical stimulation, and during late pregnancy in rats.
Doerr, Jean C., Kristal, Dr. Mark B.
core  

Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092) [PDF]

, 2006
Background and Purpose - Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell types, including neurones, glia, and vascular cells.
Bath, Philip M.W., Dennis, Martin S., Gray, Laura J., Russell, Nigel, Sprigg, Nikola, Walker, Marion F., Willmot, Mark, Zhao, Lian   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Enhanced Low Dose Rate Sensitivity at Ultra-Low Dose Rates [PDF]

We have presented results of ultra-low dose rate irradiations (< or = 10 mrad(Si)/s) for a variety of radiation hardened and commercial linear bipolar devices. We observed low dose rate enhancement factors exceeding 1.5 in several parts.
Albarian, Rafi, Buchner, Stephen, Burns, Sam, Carts, Martin, Chaumont, Geraldine, Chen, Dakai, Cox, Stephen, Duperray, Herve, Forney, James, Holcombe, Bruce, Kruckmeyer, Kriby, LaBel, Kenneth, Little, Bradley, Ouellet, Al, Pease, Ronald, Phan, Anthony, Salzman, James   +16 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Detection of late radiation damage on left atrial fibrosis using cardiac late gadolinium enhancement magnetic resonance imaging

Advances in Radiation Oncology, 2016
Purpose: This is a proof-of-principle study investigating the feasibility of using late gadolinium enhancement magnetic resonance imaging (LGE-MRI) to detect left atrium (LA) radiation damage.
Y. Jessica Huang, PhD, Alexis Harrison, MD, Vikren Sarkar, PhD, Prema Rassiah-Szegedi, PhD, Hui Zhao, PhD, Martin Szegedi, PhD, Long Huang, PhD, Brent Wilson, MD, PhD, David K. Gaffney, MD, PhD, Bill J. Salter, PhD   +9 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

MegaVoltage Radiation Dose Enhancement in Polymer Gel Dosimeter Containing Gold Nanoparticles

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2013
BACKGROUND AND OBJECTIVE: Today only three-dimensional dosimetry is used by polymer gel that it is sensitive to beam and in the recent decade it has been paid attention very much.
M Khadem Abolfazli, SR Mahdavi, M Mahdavi, GH.R Ataei   +3 more
doaj  

Four-dimensional Cone Beam CT Reconstruction and Enhancement using a Temporal Non-Local Means Method

, 2012
Four-dimensional Cone Beam Computed Tomography (4D-CBCT) has been developed to provide respiratory phase resolved volumetric imaging in image guided radiation therapy (IGRT).
Ahmad, Bergner, Buades, Combettes, Coupe, Dietrich, Feldkamp, Gilboa, Golub, Gu, Gu, Gu, Gu, Hale, Herk, Hestenes, Hissoiny, Jan-Jakob Sonke, Jia, Jia, Jia, Jia, Jia, Kriminski, Leng, Leng, Li, Li, Li, Lou, Lu, Lu, Men, Men, Samant, Segars, Sharp, Siddon, Sonke, Steve B. Jiang, Tian, Xu, Xun Jia, Yifei Lou, Zhang, Zhen Tian, Zijp   +46 more
core   +1 more source

Tumor dose enhancement by nanoparticles during high dose rate ¹⁹² Ir brachytherapy

Journal of Cancer Research and Therapeutics, 2015
The present study aims to evaluate and compare the dose enhancement factor (DEF) of tumor injected with different nanoparticles (NPs) around high dose rate (HDR) (192)Ir brachytherapy source.Monte Carlo calculations were performed with MCNPX code to determine the DEF caused by in tumor injected with (79)Au, (64)Gd, (26)Fe, and (22)Ti NPs during HDR ...
Mansour, Zabihzadeh, Sahar, Arefian
openaire   +2 more sources